3,3'-dipropyl-2,2'-thiadicarbocyanine

potent inhibitor of endogenous respiration of Ehrlich ascites tumor cells; RN given refers to iodide; RN for parent cpd not in Chemline 10/24/83; structure

Also Known As:

3,3'-bis(propylthia)dicarbocyanine; 3,3'-dipropyl-2,2'-thiadicarbocyanine chloride; 3,3'-dipropyl-2,2'-thiadicarbocyanine thiocyanate; 3,3'-dipropylthiacarbocyanine iodide; 3,3'-dipropylthiodicarbocyanine iodide; DPTDCI; DiSC3(5); diS C3-(5); diS-C3-(5); 3-propyl-2-(5-(3-propyl-2(3H)-benzothiazolylidene)- 1,3-pentadienyl)benzothiazolium iodide

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 03/15/1989 - "Measurements of cell volume changes, free cytosolic Ca2+ concentration [( Ca2+]i) with Fura 2 and cell membrane potential with 3,3'-dipropylthiodicarbocyanine iodide were used to study the effect of cell volume change on Ca2+ influx and the membrane potential of the osteoblastic osteosarcoma cell line, UMR-106-01. "
2.	Hypertension (High Blood Pressure) 08/01/1985 - "The fluorescent dye 3,3'-dipropylthiadicarbocyanine iodide, dis-C3-(5), was used to study the membrane potential of platelets in rats with renal, DOCA-induced and spontaneous hypertension. "
3.	Ehrlich Tumor Carcinoma 07/31/1980 - "The effect of the fluorescent probe, 3,3'-dipropylthiodicarbocyanine iodide, on the membrane potential of Ehrlich ascites tumor cells." 01/01/1979 - "The mechanism of inhibition on the endogenous respiration of Ehrlich ascites tumor cells by the cyanine dye diS-C3-(5)." 01/01/1979 - "The cyanine dye 3,3'-dipropyl-2,2'-thiadicarbocyanine iodide [diS-C3(5)] was found to be a potent inhibitor of endogenous respiration of Ehrlich ascites tumor cells. " 06/17/1976 - "1. The fluorescent intensity of the dye 3,3'-dipropylthiodicarbocyanine iodide was measured in suspensions of Ehrlich ascites tumor cells in an attempt to monitor their membrane potentials under a variety of different ionic and metabolic conditions. "
4.	Neoplasms (Cancer) 01/01/1989 - "Monitoring the effect of an anti-cancer drug on RPMI 4788 cells by a membrane potential probe, dis-C3-(5)."
5.	Myeloid Leukemia (Leukemia, Myelocytic) 02/01/1991 - "The membrane potential responsiveness of human myeloid leukemia cells (ML-1 line) was studied with the voltage sensitive fluorescent dye diS-C3-(5). "

Related Drugs and Biologics

1.	Fluorescent Dyes (Fluorescent Probes)
2.	Iodides
3.	Desoxycorticosterone Acetate (DOCA)
4.	Fura-2 (Fura 2)
5.	Coloring Agents (Dyes)
6.	Suspensions