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bis(monoacylglyceryl)phosphate

Also Known As:

LBPA cpd; bis(monoacylglycero)phosphate; bis(monoacylglycerol)phosphate; lysobisphosphatidic acid

Networked: 48 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Lysophospholipids: 554
        bis(monoacylglyceryl)phosphate: 48
- Glycerides: 109
  - Monoglycerides: 115
    - bis(monoacylglyceryl)phosphate: 48

Experts

1.	Canisius, Antje: 2 articles (12/2021 - 01/2021)
2.	Hollerbach, Anne: 2 articles (12/2021 - 01/2021)
3.	Lackner, Karl J: 2 articles (12/2021 - 01/2021)
4.	Müller-Calleja, Nadine: 2 articles (12/2021 - 01/2021)
5.	Pedrosa, Denise: 2 articles (12/2021 - 01/2021)
6.	Ruf, Wolfram: 2 articles (12/2021 - 01/2021)
7.	Teyton, Luc: 2 articles (12/2021 - 01/2021)
8.	Han, Xianlin: 2 articles (01/2021 - 05/2015)
9.	Martin, Douglas R: 2 articles (01/2020 - 05/2015)
10.	Liebisch, Gerhard: 2 articles (12/2018 - 01/2014)

Related Diseases

1.	Gaucher Disease (Gaucher's Disease) 06/01/2013 - "Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease."
2.	Niemann-Pick Diseases (Niemann Pick Disease) 01/07/1983 - "In all forms of Niemann-Pick disease, bis(monoacylglycero)phosphate was markedly elevated. " 01/01/1986 - "Accumulations of sphingomyelin and bis(monoacylglycero)phosphate were demonstrated in spleen from types A and B and group C Niemann-Pick disease, whereas only in type A Niemann-Pick brain was the sphingomyelin concentration increased. " 04/15/1986 - "On the basis of earlier studies of rabbit pulmonary alveolar macrophages, the incorporation of 14C-labelled polyunsaturated fatty acids into the lipids of human fibroblasts from patients with various phenotypes of Niemann-Pick disease was examined in order to define further the disturbance in metabolism of bis(monoacylglycero)phosphate occurring in these disorders. " 07/01/2010 - "We examined the effect of Niemann-Pick disease type 2 (NPC2) protein and some late endosomal lipids [sphingomyelin, ceramide and bis(monoacylglycero)phosphate (BMP)] on cholesterol transfer and membrane fusion. "
3.	Neoplasms (Cancer) 08/31/2018 - "Studies indicate alterations of bis(monoacylglycero)phosphate (BMP) species in diseases such as cancer. " 10/03/2014 - "Binding of Hsp70 to an endolysosomal phospholipid, bis(monoacylglycero)phosphate (BMP), has been recently shown to stabilize lysosomal membranes by enhancing acid sphingomyelinase (ASM) activity in cancer cells. "
4.	Cognitive Dysfunction 01/01/2020 - "The observed association of bis(monoacylglycerol)phosphate isoforms with LRRK2 G2019S mutation, PD status among G2019S carriers, and correlation with cognitive decline suggest the potential use of urinary bis(monoacylglycerol)phosphate isoforms as biomarkers for clinical trials of LRRK2-targeted therapies. "
5.	Tay-Sachs Disease 01/01/2020 - "In this paper we describe our results from a longitudinal biochemical study of a feline model of Sandhoff disease and an ovine model of Tay-Sachs disease to investigate the accumulation of GM2/GA2 gangliosides, a secondary biomarker for phospholipidosis, bis-(monoacylglycero)-phosphate, and soluble glycan metabolites in both tissue and fluid samples from both animal models. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Lipids
3.	Gangliosides
4.	Polysaccharides (Glycans)
5.	Protein Isoforms (Isoforms)
6.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
7.	Sphingomyelins
8.	Phospholipids (Phosphatides)
9.	Cholesterol
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics