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anagyrine

RN given refers to (7R-(7alpha,7abeta,14alpha))-isomer; structure

Also Known As:

7,7a,8,9,10,11,13,14-octahydro-7,14-memethano-4H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocin-4-one

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198

Experts

1.	Allam, Ahmed E: 1 article (06/2022)
2.	Aly, Shaza H: 1 article (06/2022)
3.	Eldahshan, Omayma A: 1 article (06/2022)
4.	Elissawy, Ahmed M: 1 article (06/2022)
5.	Elshanawany, Mohamed A: 1 article (06/2022)
6.	Farag, Shaimaa M: 1 article (06/2022)
7.	Singab, Abdel Nasser B: 1 article (06/2022)
8.	Gay, Clive C: 1 article (11/2004)
9.	Gay, John M: 1 article (11/2004)
10.	Hjartarson, Steven W: 1 article (11/2004)

Related Diseases

1.	Congenital Abnormalities (Deformity) 02/01/1988 - "Anagyrine-induced congenital defects." 11/01/1989 - "A congenital deformity condition called crooked calf disease, of widespread occurrence in western North America, is known to be induced by maternal ingestion during gestation of certain members of the Lupinus genus containing the quinolizidine alkaloid teratogen anagyrine. "
2.	Neoplasms (Cancer) 06/01/2022 - "Anagyrine (6) exhibited IC50 values of 27.3 ± 0.7 and 30.2 ± 0.9 µg/mL against MCF-7 and HEPG-2 cancer cells, respectively."
3.	Necrosis 08/01/1990 - "An alkaloid preparation containing mostly anagyrine from a Lupinus sp. and an alkaloid preparation containing only cytisine from Laburnum anagyroides each caused microscopic skeletal muscle degeneration and necrosis similar to, but less severe than, the alkaloid extract from T. "
4.	Contracture 02/01/1999 - "The most widespread problem for livestock producers in recent times has been lupine-induced "crooked calf disease." Crooked calf disease is characterized as skeletal contracture-type malformations and occasional cleft palate in calves after maternal ingestion of lupines containing the quinolizidine alkaloid anagyrine during gestation days 40-100. "
5.	Cleft Palate (Palate, Cleft) 02/01/1999 - "The most widespread problem for livestock producers in recent times has been lupine-induced "crooked calf disease." Crooked calf disease is characterized as skeletal contracture-type malformations and occasional cleft palate in calves after maternal ingestion of lupines containing the quinolizidine alkaloid anagyrine during gestation days 40-100. "

Related Drugs and Biologics

1.	Alkaloids
2.	Quinolizidine Alkaloids
3.	Teratogens
4.	cytisine