2-amino-4-phosphonobutyric acid

glutamate antagonist in locust muscle; structure; do not confuse with L-AP4, which is the propionic acid version

Also Known As:

2-amino-4-phosphonobutanoic acid; Abu(P); DL-2-amino-4-phosphobutanoic acid; DL-AP4; L-2-amino-4-phosphobutyric acid; L-2-amino-4-phosphonobutanoic acid; L-2-amino-4-phosphonobutyrate; L-AP4, butyric; L-APB

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bjerklund Johansen, Truls E: 1 article (06/2018)
2.	Cai, Tommaso: 1 article (06/2018)
3.	Cocci, Andrea: 1 article (06/2018)
4.	Di Maida, Fabrizio: 1 article (06/2018)
5.	Malossini, Gianni: 1 article (06/2018)
6.	Mirone, Vincenzo: 1 article (06/2018)
7.	Palmieri, Alessandro: 1 article (06/2018)
8.	Puglisi, Marco: 1 article (06/2018)
9.	Tiscione, Daniele: 1 article (06/2018)
10.	Verze, Paolo: 1 article (06/2018)

Related Diseases

1.	Ganglion Cysts (Ganglion) 02/01/1995 - "1. In this report we describe extracellular recordings made from directionally selective (DS) ganglion cells in the rabbit retina during perfusion with 2-amino-4-phosphonobutyric acid (APB) to block ON channels through the retina. " 03/01/1994 - "In contrast, an increase in resting firing rates was observed when L-APB was applied to some OFF-center ganglion cells. " 01/01/1983 - "The effects of 2-amino-4-phosphonobutyric acid (APB) on the ERG and ganglion cell discharge of rabbit retina." 01/09/1981 - "When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. " 11/07/1995 - "When transmission between rods and rod depolarizing bipolar cells was blocked by the glutamate agonist 2-amino-4-phosphonobutyric acid (APB), rod input to all On-center and briskly responding Off-center ganglion cells was dramatically reduced as expected. "
2.	Tetanus 05/01/1995 - "2-amino-5-phosphovalerate, 3-[(+/-)-2-carboxypiperazine-4-yl]-propyl-1-phosphonate or dibenzocycloheptaneimine, N-methyl-D-aspartate receptor inhibitors, abolished enhancement by tetanus, whereas, 6,7-dinitroquinoxaline-2,3-dione, an antagonist of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid ionotropic receptors, or L-2-amino-4-phosphonobutyrate, an antagonist of glutamate metabotropic receptors, showed no effect. "
3.	Parkinson Disease (Parkinson's Disease) 08/01/2012 - "We recently reported that broad spectrum agonist-induced activation of presynaptic group III metabotropic glutamate (mGlu) receptors within the substantia nigra pars compacta using L-2-amino-4-phosphonobutyrate provided functional neuroprotection in the 6-hydroxydopamine lesion rat model of Parkinson's disease. "
4.	Ischemia 11/01/2007 - "Following ischemia/reperfusion, rod bipolar cells maintained 2-amino-4-phosphonobutyric acid-responsive metabotropic glutamate receptors and displayed no change in sensitivity to flashes of light as assessed by ERG. "
5.	Catalepsy 07/01/1996 - "We have previously reported that 2-amino-4-phosphonobutyric acid (AP4), an agonist of presynaptically located metabotropic glutamate receptors, administrated at a single intracerebroventricular (icv) injection facilitated learning and memory in a passive- and learning in an active avoidance situation, enhanced apomorphine stereotypy, and attenuated haloperidol catalepsy in rats. "

Related Drugs and Biologics

1.	Excitatory Amino Acid Agonists
2.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
3.	Glutamic Acid (Glutamate)
4.	Acids
5.	Organophosphonates (Phosphonates)
6.	Excitatory Amino Acids
7.	Oxidopamine (6 Hydroxydopamine)
8.	N-Methylaspartate (NMDA)
9.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
10.	Haloperidol (Haldol)

Related Therapies and Procedures

1.	Intravitreal Injections