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allithiamine

RN given refers to parent cpd; structure

Also Known As:

allithiamine hydrochloride

Networked: 7 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiamine: 3517
      - allithiamine: 7
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Thiamine: 3517
        allithiamine: 7
  - Pyrimidines: 510
    - Thiamine: 3517
      - allithiamine: 7

Experts

1.	Remenyik, Judit: 2 articles (06/2020 - 12/2018)
2.	Stündl, László: 2 articles (06/2020 - 12/2018)
3.	Choi, Eun Jung: 1 article (11/2020)
4.	Jeon, Chang Hyun: 1 article (11/2020)
5.	Kwon, Tae-Hwan: 1 article (11/2020)
6.	Park, Dong Ho: 1 article (11/2020)
7.	Biró, Attila: 1 article (06/2020)
8.	Fazekas, Mónika Éva: 1 article (06/2020)
9.	Fidler, Gábor: 1 article (06/2020)
10.	Lukács, János: 1 article (06/2020)

Related Diseases

1.	Diabetic Neuropathies (Diabetic Neuropathy) 02/01/2005 - "The aim of the study was to evaluate the efficacy of benfotiamine administered over three weeks (allithiamine; a lipid-soluble vitamin B1 prodrug with high bioavailability) to patients with diabetic polyneuropathy in a randomized, placebo-controlled, double-blind, two-center pilot study. " 01/01/1996 - "In a double-blind, randomized, controlled study, the effectiveness of treatment with a combination of Benfotiamine (an Allithiamine, a lipid-soluble derivative of vitamin B1 with high bioavailability) plus vitamin B6/B12 on objective parameters of neuropathy was studied over a period of 12 weeks on 24 diabetic patients with diabetic polyneuropathy. "
2.	Neuralgia (Stump Neuralgia) 12/01/2018 - "The results show that neuropathic pain sensation is improved by allithiamine treatment similarly to benfothiamine."
3.	Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) 01/01/2009 - "This study was conducted to construct a basis for a therapeutic strategy against human T-lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a compound that contained a disulfide moiety, prosultiamine, which is a homologue of allithiamine originally synthesized by allicin and thiamine-thiol, for the targeting of HTLV-I-infected cells. "
4.	Endotoxemia 11/30/2020 - "We observed that allithiamine attenuated tissue damage and organ dysfunction during endotoxemia, even when the treatment was given after the early cytokine release. "
5.	Sepsis (Septicemia) 11/30/2020 - "We applied the LPS-induced sepsis model to examine whether allithiamine has a protective role in hyper-inflammatory status. " 11/30/2020 - "We then examined the clinical implication of regulating metabolites during sepsis by performing a tail bleeding assay upon allithiamine treatment, which expands its capacity to hamper the coagulation process. " 11/30/2020 - "Allithiamine Exerts Therapeutic Effects on Sepsis by Modulating Metabolic Flux during Dendritic Cell Activation."

Related Drugs and Biologics

1.	benphothiamine (benfotiamine)
2.	Thiamine (Aneurin)
3.	Lipids
4.	Prodrugs
5.	Vitamin B 6
6.	Sulfhydryl Compounds (Thiols)
7.	Disulfides
8.	prosultiamine
9.	allicin
10.	Therapeutic Uses