C 264

RN given refers to parent cpd; structure

Also Known As:

2-nitro-9-(3'-N,N-dimethylaminopropyl)aminoacridine; C 264 dihydrochloride; C-264; N,N-dimethyl-N'-(2-nitro-9-acridinyl)-1,3-propanediamine

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Aminoacridines: 3
        Nitracrine: 46
        C 264: 4

Experts

1.	Lin, Liyun: 1 article (07/2019)
2.	Song, Shujuan: 1 article (07/2019)
3.	Wang, Zhe: 1 article (07/2019)
4.	Yuan, Yun: 1 article (07/2019)
5.	Bierau, Jörgen: 1 article (01/2017)
6.	Gottschalk, Ralph W: 1 article (01/2017)
7.	Habets, Daphna D: 1 article (01/2017)
8.	Hellebrekers, Debby M E I: 1 article (01/2017)
9.	Hendrickx, Alexandra T M: 1 article (01/2017)
10.	Hoeijmakers, Janneke G J: 1 article (01/2017)

Related Diseases

1.	Congenital Hyperinsulinism 06/01/2008 - "In family 1, a frameshift mutation L330fsdel17ins9 (c.987 1003del17ins9; p.Leu330fs) was present in the proband; a mutation affecting the conserved A nucleotide of the intron 2 branch site (c.264-21A>G) was identified in the proband of family 2; and finally a nonsense mutation, Y16X (c.48C>G, p.Tyr16X), was found in the proband of family 3. Heterozygous HNF4A mutations can therefore cause both transient and persistent hyperinsulinemic hypoglycemia associated with macrosomia. "
2.	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 07/10/2019 - "Patient 2 carried a c.264_264+4delTGTAA mutation, which led to loss of splicing donor site for intron 4, and manifested Becker muscular dystrophy (BMD). "
3.	Muscle Weakness 01/01/2017 - "In a 51-year-old patient of consanguineous parents with a severe neuromuscular phenotype of early-onset ataxia, myoclonia, dysarthria, muscle weakness and exercise intolerance, exome sequencing revealed a novel homozygous variant (c.-264_31delinsCTCACAAATGCTCA) in the mitochondrial FAD-transporter gene SLC25A32. "
4.	Neoplasms (Cancer) 08/01/2010 - "Interestingly, an additional PTCH1 mutation, c.264_265insAATA, that was not present in the peripheral blood, was found in the maxillary tumor but not the mandibular tumor. "
5.	Dysarthria (Spastic Dysarthria) 01/01/2017 - "In a 51-year-old patient of consanguineous parents with a severe neuromuscular phenotype of early-onset ataxia, myoclonia, dysarthria, muscle weakness and exercise intolerance, exome sequencing revealed a novel homozygous variant (c.-264_31delinsCTCACAAATGCTCA) in the mitochondrial FAD-transporter gene SLC25A32. "

Related Drugs and Biologics

1.	Nonsense Codon (Nonsense Mutation)
2.	Nucleotides
3.	Flavin-Adenine Dinucleotide (FAD)