compound 17

structure

Also Known As:

5-acetamido-2,4,6-triiodo-N,N'-di-(2,3-dihydroxypropyl)-N,N'-dimethylisophthalamide; 1,3-Benzenedicarboxamide, 5-(acetylamino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-N,N'-dimethyl-

Networked: 85 relevant articles (6 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Iodobenzoates
        Triiodobenzoic Acids: 2
        Iohexol: 681
        compound 17: 85
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Iodobenzoates
        Triiodobenzoic Acids: 2
        Iohexol: 681
        compound 17: 85

Experts

1.	Chuang, Kuo-Hsiang: 2 articles (06/2022 - 03/2020)
2.	Liou, Jing-Ping: 2 articles (06/2022 - 03/2020)
3.	Nepali, Kunal: 2 articles (06/2022 - 03/2020)
4.	Wu, Tung-Yun: 2 articles (06/2022 - 03/2020)
5.	Funk, Petr: 2 articles (01/2021 - 01/2018)
6.	Lemrová, Barbora: 2 articles (01/2021 - 01/2018)
7.	Soural, Miroslav: 2 articles (01/2021 - 01/2018)
8.	Vanda, David: 2 articles (01/2021 - 01/2018)
9.	Zajdel, Paweł: 2 articles (01/2021 - 01/2018)
10.	Salvador, Jorge A R: 2 articles (08/2019 - 11/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "A seven membered ring compound, 17, was found to be the most potent with sub-micromolar IC50s in breast (0.76μM) and ovarian (0.76μM) cancer cell lines. " 04/01/2015 - "The results of the 48h incubation time in vitro tests showed that compound 15 was the most effective against PC-3 (IC50 6.6μM), compound 17 against MCF-7 (IC50 7.9μM) cells, while compound 16 exhibited strong antiproliferative effect against both, MCF-7 (IC50 1.7μM) and PC-3 (IC50 8.7μM) cancer cells. " 11/01/2019 - "Compared to the marketed compound 17, compound 13 not only induced regressions in colorectal and pancreatic tumor models, it also exhibited at least 5-fold enhancement in antitumor efficacy with only 40% of the drug employed during treatment, culminating in a >12.5-fold increase in therapeutic potential. " 01/01/2021 - "Moreover, fluorescent staining studies showed compound 17 could induce cancer cells apoptosis. " 01/01/2021 - "In in vivo studies, compound 17 demonstrated a good bioavailability (73.6%) and significantly suppressed tumor growth in MV4-11 (10 mg/kg, TGI 93.4%) and MOLM-13 (20 mg/kg, TGI 98.0%) xenograft models without exhibiting obvious toxicity. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "Compound 17 was found to be the most potent against breast cancer cell lines with IC55 value 66.6 μM compared with the reference drug 5-fluorouracil with IC50 value 77.28 μM." 01/01/2020 - "Mechanistically, compound 17 induced a strong dissipation of the mitochondrial transmembrane potential and an early activation of caspase 3/7 in the triple-negative MDA-MB-231 breast cancer cell line. " 11/01/2011 - "Most of the arylboronic acid derivatives of indoquinolines inhibited human breast cancer cell (MDA-231) proliferation at a concentration of 5 μm, whereas the compound 17 exhibited highest percentages (76.74%) of the cancer cell proliferation inhibition." 01/01/2013 - "Based on the reported anticancer activity of quinolines, a new series of 7-chloroquinoline derivatives bearing the biologically active benzenesulfonamide moiety 2-17 and 19-25 were synthesized starting with 4,7-dichloroquinolne 1. Compound 17 was the most active compound with IC(50) value 64.41, 75.05 and 30.71 µM compared with Doxorubicin as reference drug with IC(50) values 82.53, 88.32 and 73.72 µM on breast cancer cells, skin cancer cells and neuroblastoma, respectively. "
3.	Pancreatic Neoplasms (Pancreatic Cancer) 12/12/2019 - "Compound 17 exhibited antitumor efficacy with no significant toxicity in xenograft models of pancreatic cancer. " 03/10/2018 - "These results demonstrate outstanding capability of compound 17 as a potent photosensitizer which could improve the PDT efficacy in pancreatic cancer patients."
4.	Phototoxic Dermatitis (Phototoxicity) 03/10/2018 - "Compound 17 showed excellent PDT efficacy with IC50 of 40, 35 and 41 nM against AsPC-1, MIA PaCa-2 and PANC-1 respectively with exceptional dark/phototoxicity ratio in the range of 2371-7500. "
5.	Inflammation (Inflammations) 12/01/2020 - "Taken together, these results show that compound 17 might play protective role in inflammatory bone destruction through inhibiting osteoclastogenesis and inflammation. " 12/01/2020 - "In vivo experiments showed that compound 17 could effectively protect mice from LPS-induced inflammatory bone destruction by inhibiting osteoclastogenesis and inflammation. " 10/17/2022 - "The results attained in this study indicated that compound 17 had the potential to be developed into an anti-inflammation and analgesic agent." 10/01/2020 - "In the evaluation of compounds on their inhibitory actions against TNF-α-induced adhesion of monocytic cells to colonic epithelial cells, an in vitro model mimicking colon inflammation, the effects of compounds 9, 17, and 19 were greater than tofacitinib, an orally available anti-colitis drug, and compound 17 showed the greatest activity. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	1-phenyl-3,3-dimethyltriazene (PDT)
3.	Analgesics (Analgesic Drugs)
4.	triphosphoric acid (triphosphate)
5.	Lipopolysaccharides
6.	pyridine
7.	Voltage-Gated Sodium Channels
8.	B7-H1 Antigen
9.	Group X Phospholipases A2
10.	Amyloid Precursor Protein Secretases (beta-Secretase)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Ligation
4.	Subcutaneous Injections
5.	Castration