trichostatin A (A 300)

chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES

Also Known As:

Networked: 1201 relevant articles (54 outcomes, 180 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kavoosi, Fraidoon: 11 articles (06/2021 - 12/2017)
2.	Sanaei, Masumeh: 10 articles (06/2021 - 12/2017)
3.	Donadelli, Massimo: 9 articles (01/2018 - 06/2003)
4.	Ma, Ding: 9 articles (01/2018 - 09/2005)
5.	Scarpa, Aldo: 9 articles (04/2009 - 06/2003)
6.	Wu, Peng: 8 articles (01/2020 - 09/2005)
7.	Palmieri, Marta: 8 articles (04/2009 - 06/2003)
8.	Wang, Hui: 6 articles (01/2020 - 09/2005)
9.	Yeh, Shu-Lan: 6 articles (06/2019 - 02/2010)
10.	Cecconi, Daniela: 6 articles (01/2018 - 06/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2007 - "The aim of this study was to evaluate the in vitro tumoricidal activity of the Apo2L/TRAIL + Trichostatin A in cultured thoracic cancer cells and to elucidate the molecular basis of the synergistic cytotoxicity of this combination. " 01/01/2021 - "Low Dose of Trichostatin A Improves Radiation Resistance by Activating Akt/Nrf2-Dependent Antioxidation Pathway in Cancer Cells." 01/01/2021 - "Trichostatin A was the most potent agent for ampullary cancer with a half maximal inhibitory concentration of < 0.3 μM. " 11/18/2020 - "In conclusion, both HDACi treatments diminished the inherent tumorigenic growth potential of the tumor embryonal source, although Trichostatin A did not diminish the potentially dangerous expression of cancer-related genes and the amount of CSCLC." 12/01/2014 - "Trichostatin A induces mesenchymal-like morphological change and gene expression but inhibits migration and colony formation in human cancer cells."
2.	Lung Neoplasms (Lung Cancer) 01/01/2018 - "Trichostatin A reverses the chemoresistance of lung cancer with high IGFBP2 expression through enhancing autophagy." 10/01/2014 - "Then it was used to retrieve relevant small molecule drugs with Connectivity map and trichostatin A was predicted to be the top candidate drug for treatment of lung cancer. " 08/01/2010 - "Four lung cancer cell lines lacking TRbeta1 expression were treated with 5-aza-2-deoxy-cytidine and/or trichostatin-A, and the TRbeta1 expression was determined by RT-PCR. " 04/01/2010 - "[Effects of trichostatin A on human lung cancer cell strains A549]." 02/01/2006 - "5-Aza-2'-deoxy-cytidine and/or Trichostatin A treatments induced DOCK8 expression in lung cancer cell lines with reduced DOCK8 expression. "
3.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/01/2017 - "The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord." 07/01/2005 - "Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis." 04/01/2006 - "Recently, we demonstrated the efficacy of the HDAC inhibitor Trichostatin A in ameliorating disease in the multiple sclerosis (MS) animal model, experimental autoimmune encephalomyelitis (EAE). " 01/01/2018 - "We have recently demonstrated that treatment of NOD mice with the epigenetic drug Trichostatin A (TSA) ameliorated myelin peptide induced progressive experimental autoimmune encephalomyelitis (P-EAE). " 12/01/2017 - "Here, we show that treatment of NOD mice with the histone deacetylase inhibitor, Trichostatin A affords robust protection against myelin peptide induced experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. "
4.	Multiple Sclerosis 04/01/2006 - "Recently, we demonstrated the efficacy of the HDAC inhibitor Trichostatin A in ameliorating disease in the multiple sclerosis (MS) animal model, experimental autoimmune encephalomyelitis (EAE). " 12/01/2017 - "Here, we show that treatment of NOD mice with the histone deacetylase inhibitor, Trichostatin A affords robust protection against myelin peptide induced experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. " 07/01/2005 - "We demonstrate that the histone deacetylase (HDAC) inhibitor drug trichostatin A (TSA) reduces spinal cord inflammation, demyelination, neuronal and axonal loss and ameliorates disability in the relapsing phase of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). "
5.	Leukemia 08/01/2006 - "[Mechanism of apoptosis induced by trichostatin A in leukemia Molt-4 cells analyzed by microarray]." 09/01/1990 - "Structural specificity for biological activity of trichostatin A, a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells." 02/01/2009 - "Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A." 08/01/2006 - "Trichostatin A improves the anticancer activity of low concentrations of curcumin in human leukemia cells." 11/01/2005 - "Quercetin and trichostatin A cooperatively kill human leukemia cells."

Related Drugs and Biologics

1.	Histone Deacetylase Inhibitors
2.	theasinensin A
3.	Vorinostat
4.	Valproic Acid (Depakote)
5.	Histone Deacetylases (Histone Deacetylase)
6.	Decitabine
7.	Cisplatin (Platino)
8.	DNA (Deoxyribonucleic Acid)
9.	4-phenylbutyric acid (Buphenyl)
10.	Lidocaine (Xylocaine)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Intramuscular Injections
5.	Solid-State Lasers