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trichostatin A (A 300)

chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES
Also Known As:
A 300; TSA antibioitc; tricostatin A; trychostatin A; 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide
Networked: 882 relevant articles (29 outcomes, 123 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Scarpa, Aldo: 9 articles (04/2009 - 06/2003)
2. Donadelli, Massimo: 8 articles (04/2009 - 06/2003)
3. Palmieri, Marta: 8 articles (04/2009 - 06/2003)
4. Ma, Ding: 7 articles (02/2015 - 09/2005)
5. Karagiannis, Tom C: 6 articles (08/2012 - 10/2010)
6. Zhou, Jianfeng: 5 articles (01/2014 - 09/2005)
7. Wu, Peng: 5 articles (01/2014 - 09/2005)
8. Kook, Hyun: 5 articles (11/2011 - 09/2003)
9. Righetti, Pier Giorgio: 5 articles (04/2009 - 06/2003)
10. Cecconi, Daniela: 5 articles (04/2009 - 06/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Lung Neoplasms (Lung Cancer)
3. Leukemia
4. Lung Injury
5. Multiple Sclerosis

Related Drugs and Biologics

1. Histone Deacetylase Inhibitors
2. vorinostat (suberoylanilide hydroxamic acid)
3. Histone Deacetylases (Histone Deacetylase)
4. Valproic Acid (Valproate, Semisodium)
5. Cisplatin (Platino)
6. Lidocaine (Xylocaine)
7. Butyrates (Butyrate)
8. Sodium
9. decitabine (5-aza-2'-deoxycytidine)
10. Chromatin

Related Therapies and Procedures

1. Intramuscular Injections
2. Solid-State Lasers
3. Ovariectomy (Oophorectomy)
4. Hysterectomy
5. Drug Therapy (Chemotherapy)