|1.||Mangel, A W: 1 article (01/2008)|
|2.||Kassem, N: 1 article (01/2008)|
|3.||Frissora, C L: 1 article (01/2008)|
|4.||Keogh, J C: 1 article (01/2008)|
|5.||Leventer, S M: 1 article (01/2008)|
|6.||Raudibaugh, K: 1 article (01/2008)|
|7.||Phillips, J: 1 article (01/2008)|
|8.||Beloborodova, E I: 1 article (01/2005)|
|9.||Tóth, Mária: 1 article (01/2005)|
|10.||Drabant, Sándor: 1 article (01/2005)|
05/01/2003 - "[A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia]."
05/01/1987 - "Antiarrhythmic activity of psychotropic agents, such as phenibut, eglonyl, azaphen, grandaxin, fali-lepsin, is demonstrated for the first time ever in patients with paroxysmal supraventricular tachycardia, atrial fibrillation and ventricular extrasystole. "
|2.||Cardiac Arrhythmias (Arrythmia)
|3.||Congenital Abnormalities (Deformity)
11/01/1982 - "Even though tofizopam has no anticonvulsive action against pentetrazol-induced convulsions, it significantly potentiated the action of diazepam but with no modification of brain diazepam levels and metabolism. "
02/01/1983 - "Tofizopam enhances the action of diazepam against tremor and convulsions."
02/01/1983 - "Convulsions induced by harmane were not affected by tofizopam (50-300 mg/kg), but diazepam (15 mg/kg) increased the ED50 of harmane from 9.9 to 25.1 mg/kg. Tofizopam did not alter the threshold for electroshock-induced convulsions, while a dose of 10 mg/kg diazepam protected mice from convulsions. "
01/01/1986 - "Although several anticonvulsants act on the GABA-BZ receptor complex, tofizopam seems to modify selectively the anticonvulsive action of 1,4-BZs, and this effect is seen better in bicuculline-induced seizures than in electroshocks."
06/01/1983 - "Tofisopam (1.0 mg/kg, iv, or 0.1 mg/kg by intracerebrospinal injection) inhibited the constriction of ear microvessels, the decrease in earlobe temperature, and mydriasis induced by electrical stimulation of the medial hypothalamic area in rabbits. "
09/01/1981 - "This increase was reversed to control levels after the oral administration of tofisopam in a dose of 100 mg/kg. Tofisopam at dose of 1 mg/kg i.v. inhibited the contraction of ear microvessels, the decrease in earlobe temperature and the mydriasis induced by electrical stimulation of the medial hypothalamic area in rabbits, Moreover, these inhibitions were also shown by the intra-cerebrospinal injection of tofisopam at a dose of 0.1 mg/kg. From these results, it is concluded that tofisopam could restore the autonomic abnormality induced by stress-loading and exerts such effects by acting on the hypothalamus, an area of the brain, which regulates autonomic nervous functions."
|7.||gamma-Aminobutyric Acid (GABA)
|9.||Anticonvulsants (Antiepileptic Drugs)