tofisopam

structure; dextofisopam is the R-enantiomer of tofisopam & antidiarrheal

Also Known As:

1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine; EGYT-341; Grandaxin; dextofisopam; levotofisopam; tofizopam; 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy- 4-methyl-5H-2,3-benzodiazepine

Networked: 28 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        tofisopam: 28

Experts

1.	Can, Özgür Devrim: 1 article (01/2020)
2.	Demir Özkay, Ümide: 1 article (01/2020)
3.	Ulupinar, Emel: 1 article (01/2020)
4.	Üçel, Umut İrfan: 1 article (01/2020)
5.	Merriman, Tony R: 1 article (01/2018)
6.	Singh, Jasvinder A: 1 article (01/2018)
7.	Stamp, Lisa K: 1 article (01/2018)
8.	Arakawa, Tetsuo: 1 article (03/2016)
9.	Fujikawa, Yoshiko: 1 article (03/2016)
10.	Fujiwara, Yasuhiro: 1 article (03/2016)

Related Diseases

1.	Ventricular Tachycardia 05/01/2003 - "[A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia]." 05/01/1987 - "Antiarrhythmic activity of psychotropic agents, such as phenibut, eglonyl, azaphen, grandaxin, fali-lepsin, is demonstrated for the first time ever in patients with paroxysmal supraventricular tachycardia, atrial fibrillation and ventricular extrasystole. "
2.	Abdominal Pain (Pain, Abdominal) 03/01/2016 - "Tofisopam partially improved autonomic nervous system dysfunction and abdominal pain/indigestion. " 01/15/2008 - "Dextofisopam and placebo had similar rates and types of adverse events, with more events of worsening abdominal pain with dextofisopam (12% vs. 4%) and more headaches with placebo (12% vs. 5%). "
3.	Dyspepsia (Indigestion) 03/01/2016 - "To elucidate the role of autonomic nervous system in functional dyspepsia patients, we examined 24-h heart rate variability: the basal levels, responses after lunch, cold pressor and mental arithmetic tests, and the efficacy of an autonomic drug (tofisopam). " 03/01/2016 - "Tofisopam partially improved autonomic nervous system dysfunction and abdominal pain/indigestion. "
4.	Cardiac Arrhythmias (Arrythmia) 05/01/2003 - "In this case report, the frequency of PSVT was significantly decreased and subjective symptoms of arrhythmia were eliminated after the administration of tofisopam. "
5.	Lower Urinary Tract Symptoms 09/01/1989 - "[Clinical studies on tofisopam in patients with lower urinary tract symptoms]." 09/01/1989 - "These results suggest that tofisopam is an effective drug to treat lower urinary tract symptoms." 09/01/1989 - "The clinical effects of tofisopam were studied on 29 patients with lower urinary tract symptoms. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Anti-Anxiety Agents (Anxiolytics)
3.	Scopolamine (Hyoscine)
4.	Nitrazepam (Serenade)
5.	Medazepam
6.	Clonazepam (Rivotril)
7.	Uric Acid (Urate)
8.	Diazepam (Valium)
9.	Sulpiride (neogama)
10.	GABA-A Receptors (GABA(A) Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration