roquefortine

metabolite of Penicillium roqueforti; structure

Also Known As:

isoroquefortine C; roquefortin; roquefortine C; 2H-pyrazino(1',2':1,5)pyrrolo(2,3-b)indole-1,4(3H,5aH)-dione, 10b-(1,1-dimethyl-2-propenyl)-6,10b,11,11a-tetrahydro-3-(1H-imidazol-4-ylmethylene)-

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - roquefortine: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - roquefortine: 10
  - 4 or More Rings Heterocyclic Compounds
    - roquefortine: 10

Experts

1.	Bashmakov, Yuriy K: 1 article (12/2012)
2.	Petyaev, Ivan M: 1 article (12/2012)
3.	Bernhoft, A: 1 article (02/2010)
4.	Eriksen, G S: 1 article (02/2010)
5.	Jaeger, G: 1 article (02/2010)
6.	Jäderlund, K Hultin: 1 article (02/2010)
7.	Moldes-Anaya, A: 1 article (02/2010)
8.	Rundberget, T: 1 article (02/2010)
9.	Schönheit, J: 1 article (02/2010)
10.	Skaar, I: 1 article (02/2010)

Related Diseases

1.	Body Weight (Weight, Body) 09/01/2005 - "This study examined dose-response (0.5 nM, 2.5 nM, 5.0 nM, 12.5 nM/g body weight (BW) animal) and time-course (3, 6, 24 and 48 h post instillation (PI)) relationships associated with inflammatory and cytotoxic responses in mouse lungs intratracheally instilled with pure brevianamide A, mycophenolic acid, and roquefortine C. "
2.	Poisoning 02/01/2010 - "Penitrem A was found in all reported poisonings and roquefortine C in all cases when this toxin was included in the analysis. " 05/01/2002 - "Penitrem A and roquefortine poisonings were diagnosed in a Laborador retriever following garbage consumption. " 05/01/2002 - "Acute penitrem A and roquefortine poisoning in a dog." 08/01/1992 - "The inability to differentiate between roquefortine and strychnine poisoning on a clinical basis in five of our six cases emphasizes that an accurate causative diagnosis requires laboratory examination.Research" 08/01/1992 - "Roquefortine in the stomach contents of dogs suspected of strychnine poisoning in Alberta."
3.	Neoplasms (Cancer) 04/03/2023 - "Meleagrin and oxaline, which belong to the roquefortine alkaloids with a unique dihydroindole spiroamide framework, have significant bioactivities, especially tumor cell inhibitory activity. " 01/21/2023 - "With the advent of the Red Sea Penicillium chrysogenum strain S003-isolated indole-based alkaloids, we thoroughly investigated the molecular aspects for three major metabolites: meleagrin (MEL), roquefortine C (ROC), and isoroquefortine C (ISO) against three cancer-associated biological targets Cdc-25A, PTP-1B, and c-Met kinase. "
4.	Mycotoxicosis (Fungus Poisoning) 03/01/2002 - "Only aflatoxins, penitrem A, and roquefortine have been confirmed in natural mycotoxicoses in pets. "
5.	Tremor (Tremors) 11/15/2002 - "The mycotoxins identified were penitrem A and roquefortine, which are both produced by Penicillium spp. Treatment goals following tremorgenic mycotoxin ingestion include minimizing absorption, controlling tremors and seizures with methocarbamol and pentobarbital sodium administration, and providing supportive care. "

Related Drugs and Biologics

1.	Mycophenolic Acid (Cellcept)
2.	brevianamide A
3.	tremortin (penitrem A)
4.	Strychnine
5.	Alkaloids
6.	meleagrin
7.	roquefortine
8.	Phosphotransferases (Kinase)
9.	Pentobarbital (Nembutal)
10.	Mycotoxins