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acetylmuramyl-valylisoglutamine
analog of AcMu-Ala-iso-Gln, MDP = muramyldipeptide
Also Known As:
AcMu-Val-iso-Gln; MDP(Val); MurNAc-L-Val-D-isoGln; N-acetylmuramyl-L-valyl-D-isoglutamine
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Amino Sugars: 110
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
acetylmuramyl-valylisoglutamine: 2
Sugar Acids: 4
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
acetylmuramyl-valylisoglutamine: 2
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Glycopeptides: 1928
Acetylmuramyl-Alanyl-Isoglutamine: 467
acetylmuramyl-valylisoglutamine: 2
Related Diseases
1.
Hypersensitivity (Allergy)
01/01/1981 - "
coli infection; MDP(Val) was proven to be slightly less active than MDP(Ala), and MDP(Ser) to be the least effective, although MDP(Val) or MDP(Ser) was reported to have higher adjuvanticity than MDP (Ala) for the development of delayed-type hypersensitivity.
"
01/01/1981 - "
N-Acetyl muramyl-L-valyl-D-isoglutamine (MurNac-L-Val-D-isoGln), QS-10-MurNAc-L-Val-D-isoGln, and their methyl esters were shown to have potent adjuvant activity on the induction of delayed-type hypersensitivity to monoazobenzenarsonate-N-acetyl-L-tyrosine in guinea pigs and on the primary immune response against sheep erythrocytes in vitro; however, only QS-10-MurNAc-L-Val-D-isoGln methyl ester, i.e., QS-10-MurNAc-L-Val-D-Glu(OCH3)NH2 (quinonyl-MDP-66), was shown to be an active adjuvant for the induction of allogeneic killer T cells in mice and the suppression of tumor growth in syngeneic mice when it was administered as a suspension in phosphate-buffered saline.
"
2.
Neoplasms (Cancer)
01/01/1981 - "
N-Acetyl muramyl-L-valyl-D-isoglutamine (MurNac-L-Val-D-isoGln), QS-10-MurNAc-L-Val-D-isoGln, and their methyl esters were shown to have potent adjuvant activity on the induction of delayed-type hypersensitivity to monoazobenzenarsonate-N-acetyl-L-tyrosine in guinea pigs and on the primary immune response against sheep erythrocytes in vitro; however, only QS-10-MurNAc-L-Val-D-isoGln methyl ester, i.e., QS-10-MurNAc-L-Val-D-Glu(OCH3)NH2 (quinonyl-MDP-66), was shown to be an active adjuvant for the induction of allogeneic killer T cells in mice and the suppression of tumor growth in syngeneic mice when it was administered as a suspension in phosphate-buffered saline.
"
3.
Infections
01/01/1981 - "
coli infection; MDP(Val) was proven to be slightly less active than MDP(Ala), and MDP(Ser) to be the least effective, although MDP(Val) or MDP(Ser) was reported to have higher adjuvanticity than MDP (Ala) for the development of delayed-type hypersensitivity.
"
Related Drugs and Biologics
1.
Suspensions
2.
Phosphates (Orthophosphate)
3.
Esters
4.
isoglutamine
5.
N-acetyltyrosine