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alpha-methylphenylalanine

induces chronic hyperphenylalaninemia in suckling rats; models for the study of inborn errors of metabolism; RN given refers to parent cpd without isomeric designation
Also Known As:
alpha-methylphenylalanine, (D-Phe)-isomer; alpha-methylphenylalanine, (DL-Phe)-isomer; alpha-methylphenylalanine, (L-Phe)-isomer; alpha-methylphenylalanine, hydrochloride, (D-Phe)-isomer; alpha-methylphenylalanine, hydrochloride, (DL-Phe)-isomer; alpha-methylphenylalanine, hydrochloride, (L-Phe)-isomer
Networked: 15 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Wajner, Moacir: 2 articles (04/2003 - 05/2002)
2. Wannmacher, Clóvis Milton Duval: 1 article (04/2003)
3. Kessler, Adriana: 1 article (04/2003)
4. Severo Dutra-Filho, Carlos: 1 article (04/2003)
5. de Souza Wyse, Angela Terezinha: 1 article (04/2003)
6. Costabeber, Elisa: 1 article (04/2003)
7. Rech, Virginia Cielo: 1 article (05/2002)
8. Feksa, Luciane Rosa: 1 article (05/2002)
9. Wyse, Angela Terezinha de Souza: 1 article (05/2002)
10. Wannmacher, Clovis Milton Duval: 1 article (05/2002)

Related Diseases

1. Phenylketonurias (Phenylketonuria)
2. Body Weight (Weight, Body)
04/01/2003 - "Hyperphenylalaninemia was induced by subcutaneous administration of 5.2 micromol phenylalanine + 2.4 micromol alpha-methylphenylalanine (phenylalanine hydroxylase (PAH) inhibitor)/g of body weight. "
05/01/2002 - "HPA was induced by subcutaneous administration of 2.4 micromol/g body weight alpha-methylphenylalanine, a phenylalanine hydroxylase inhibitor, once a day, plus 5.2 microM/g body weight phenylalanine, twice a day, from the 6th-21st postnatal day. "
03/01/1983 - "In the first treatment, pregnant rats were injected subcutaneously with alpha-methylphenylalanine (to inhibit maternal liver phenylalanine hydroxylase) at a dosage of 30 mg/100 g body weight plus phenylalanine supplementation (to increase maternal and fetal plasma phenylalanine) at a dosage of 60 mg/100 g body weight two times daily. "
06/01/1999 - "Wistar rats were treated from the 6th to the 28th day of life with subcutaneous injections of either 2.6 micromol alanine or 5.2 micromol phenylalanine plus 2.6 micromol alpha-methylphenylalanine per g body weight or phenylalanine plus alpha-methylphenylalanine plus alanine in the same doses or equivalent volumes of 0.15 M saline. "
03/01/1983 - "High concentrations of phenylalanine were induced in pregnant rats from embryonic days 14 through 21 by subcutaneous injections of alpha-methylphenylalanine (mPhe) (to inhibit maternal phenylalanine hydroxylase) at a dosage of 30 mg/100 g body weight plus phenylalanine (Phe) supplementation (to raise fetal plasma phenylalanine) at a dosage of 60 mg/100 g body weight two times daily at 12-h intervals. "
3. Neuroblastoma
4. Acquired Immunodeficiency Syndrome (AIDS)

Related Drugs and Biologics

1. Phenylalanine (L-Phenylalanine)
2. Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
3. Tyrosine (L-Tyrosine)
4. Dopamine (Intropin)
5. Neurotransmitter Agents (Neurotransmitter)
6. Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
7. Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)
8. Fenclonine (p-Chlorophenylalanine)
9. Neutral Amino Acids
10. Norepinephrine (Noradrenaline)

Related Therapies and Procedures

1. Subcutaneous Injections
2. Injections