metanicotine

RN given refers to parent cpd with unspecified isomeric designation

Also Known As:

N-methyl-4-(3-pyridinyl)-3-buten-1-amine; N-methyl-4-(3-pyridinyl)-3-butene-1-amine; RJR 2403; RJR-2403; TC 2403; TC 2403-12; TC-2403; TC-2403-12; TC2403; metanicotine hemigalactarate; metanicotine, (E)-isomer; metanicotine, (R-(R*,R*))-2,3-dihydroxybutanedioate salt; metanicotine, (Z)-isomer; trans-metanicotine

Networked: 15 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Solanaceous Alkaloids: 4
    - Nicotine: 9957
      - metanicotine: 15
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Nicotine: 9957
      - metanicotine: 15

Experts

1.	Dar, M Saeed: 4 articles (03/2011 - 10/2006)
2.	Saeed Dar, M: 2 articles (03/2011 - 11/2008)
3.	Taslim, Najla: 2 articles (03/2011 - 03/2011)
4.	Smith, Aaron D: 2 articles (07/2007 - 10/2006)
5.	Jang, J: 2 articles (12/2001 - 06/2000)
6.	Park, H: 2 articles (12/2001 - 06/2000)
7.	Sin, K S: 2 articles (12/2001 - 06/2000)
8.	Golebiowska, Joanna: 1 article (12/2018)
9.	Nikiforuk, Agnieszka: 1 article (12/2018)
10.	Popik, Piotr: 1 article (12/2018)

Related Diseases

1.	Amnesia (Dissociative Amnesia) 12/01/1996 - "Specifically, RJR-2403 significantly improved passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats with ibotenic acid lesions of the forebrain cholinergic projection system in an 8-arm radial maze paradigm. "
2.	Hyperalgesia 11/01/1999 - "Neostigmine and RJR-2403 but not bethanechol were more potent in female than in male rats in reducing allodynia after nerve injury, and antagonist studies were also consistent with a nicotinic component to explain this sex difference. " 11/01/1999 - "In contrast, for capsaicin-induced allodynia, neostigmine plus mecamylamine but not neostigmine or RJR-2403 was more potent in female than in male rats. " 12/03/2006 - "It was found that the intrathecal injection of nicotine, RJR-2403, a selective alpha4beta2 nAChR agonist, and choline, a selective alpha7 nAChR agonist, produced an antinociceptive effect on the TNT-induced allodynia. "
3.	Ataxia (Dyssynergia) 07/01/2007 - "Intracerebellar RJR-2403 (750 ng) microinfused for 1, 2, 3, 5, and 7 days (once daily) significantly attenuated Delta(9)-THC-induced ataxia in the 3-, 5-, and 7-day treatment groups; optimal cross-tolerance was evident at day 5 and persisted till 36 h after the last RJR-2403 microinfusion. " 11/11/2008 - "RJR-2403 dose-dependently attenuated ethanol ataxia suggesting a role of alpha(4)beta(2) subtype in ameliorating ethanol-induced ataxia. " 11/11/2008 - "Using the Rotorod test and direct ICB microinfusion technique in stereotaxically cannulated CD-1 male mice, we performed the Rotorod test following ICB administration of the alpha(4)beta(2)-selective agonist, (E)-N-methyl-4-(3-pyridinyl)-3-buten-1-amine (RJR-2403; 31.25, 62.5, 125 ng) on ethanol (2 g/kg; i.p.) ataxia at 15, 30, 45, 60 min post-ethanol injection. " 10/18/2006 - "To further investigate which specific nAChR subtype was involved, ICB microinfusion of RJR-2403 (250, 375, 500, 750 ng), a alpha(4)beta(2) selective nAChR agonist, markedly attenuated Delta(9)-THC ataxia. " 03/01/2011 - "Repeated intracerebellar microinfusion of the α(4)β(2)-selective agonist, RJR-2403 (for 1, 2, 3, 5 or 7 days) or the α(7)-selective agonist, PNU-282987 (1, 2, 3 or 5 days), dose-dependently attenuated ethanol-induced ataxia. "
4.	Alzheimer Disease (Alzheimer's Disease) 12/01/2006 - "Chronic treatment with RJR-2403 and 17beta-estradiol had a pronounced antiamnestic effect under conditions of Alzheimer type dementia in middle-aged ovariectomized rats." 12/01/2006 - "Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia." 12/01/2001 - "trans-Metanicotine, a subtype (alpha4beta2)-selective ligand for neuronal nicotinic acetylcholine receptor, is under clinical phase for Alzheimer's disease. " 06/01/2000 - "trans-Metanicotine, a subtype (alpha4beta2)-selective ligand for neuronal nicotinic acetylcholine receptor, is under clinical phase for Alzheimer's disease. " 12/01/2006 - "The effects of chronic combined treatment with alpha7-nicotinic cholinergic receptor agonist RJR-2403 (1.0 mg/kg intraperitoneally) or alpha7-nicotinic cholinergic receptor antagonist mecamylamine (1.0 mg/kg intraperitoneally) and 17beta-estradiol (0.5 microg per rat intramuscularly) for 10 days on passive avoidance retention were studied in middle-aged (15 months) ovariectomized rats with experimental Alzheimer type dementia. "
5.	Schizophrenia (Dementia Praecox) 12/03/2018 - "We investigated the effects of varenicline, compared to the α4β2-nAChR partial agonist TC-2403 and the α7-nAChR full agonist PNU-282987, in a ketamine-based model of schizophrenia-like cognitive deficits on the attentional set-shifting task in rats. "

Related Drugs and Biologics

1.	Cholinergic Agents (Cholinergics)
2.	Scopolamine (Hyoscine)
3.	Ibotenic Acid
4.	Bethanechol (Duvoid)
5.	Neostigmine (Neostigmine Bromide)
6.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
7.	Nicotine
8.	PNU-282987
9.	Mecamylamine
10.	Ethanol (Ethyl Alcohol)

Related Therapies and Procedures

1.	Spinal Injections