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1'-hydroxysafrole
Also Known As:
alpha-ethenyl-1,3-benzodioxole-5-methanol
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Allylbenzene Derivatives: 4
Safrole: 67
1'-hydroxysafrole: 6
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Dioxoles
Benzodioxoles: 3
Safrole: 67
1'-hydroxysafrole: 6
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzodioxoles: 3
Safrole: 67
1'-hydroxysafrole: 6
Related Diseases
1.
Neoplasms (Cancer)
11/01/1983 - "
Thus, all of these data strongly support the conclusion that 1'-sulfoöxysafrole is the major ultimate electrophilic and tumor-initiating metabolite of 1'-hydroxysafrole.
"
12/01/1976 - "
Of the mice given a total dose of 4.4 mumoles of 1'-hydroxysafrole, 59developed hepatocellular carcinomas; 39% of the mice bore multiple liver tumors.
"
05/01/1987 - "
Under these conditions preweanling male C3H/HeJ mice were more susceptible than male C57BL/6J mice or females of either strain to liver tumor induction by 1'-hydroxyestragole (1'-hydroxy-1-allyl-4-methoxybenzene) and 1'-hydroxysafrole (1'-hydroxy-1-allyl-3,4-methylenedioxybenzene).
"
04/01/1987 - "
The hepatocarcinogen 1'-hydroxysafrole (HOS) exhibited weak initiating activity and strong promoting activity for the induction of enzyme-altered foci and tumors in rat liver.
"
04/01/1987 - "
Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.
"
2.
Hepatocellular Carcinoma (Hepatoma)
12/01/1976 - "
Of the mice given a total dose of 4.4 mumoles of 1'-hydroxysafrole, 59developed hepatocellular carcinomas; 39% of the mice bore multiple liver tumors.
"
Related Drugs and Biologics
1.
Safrole (Safrol)
2.
Pentachlorophenol (Sodium Pentachlorophenate)
3.
1'-hydroxyestragole
4.
Sulfotransferases
5.
Eugenol
6.
Enzymes
7.
Croton Oil
8.
Carcinogens
9.
Carbon Tetrachloride (Tetrachloromethane)
10.
3'-methyl-4-diethylaminoazobenzene