|1.||Ramsdell, John S: 13 articles (03/2014 - 09/2007)|
|2.||Gulland, Frances M D: 6 articles (05/2014 - 01/2005)|
|3.||Tasker, R Andrew: 5 articles (08/2014 - 01/2007)|
|4.||Tiedeken, Jessica A: 5 articles (05/2013 - 11/2007)|
|5.||Muha, Noah: 4 articles (01/2013 - 01/2011)|
|6.||Kerr, D Steven: 4 articles (07/2011 - 09/2002)|
|7.||Kerr, D S: 4 articles (09/2010 - 11/2001)|
|8.||Campbell, Katrina: 3 articles (11/2014 - 10/2013)|
|9.||Ryan, Catherine L: 3 articles (08/2014 - 01/2007)|
|10.||Wang, Zhihong: 3 articles (12/2012 - 09/2007)|
08/23/2011 - "California sea lions (Zalophus californianus) are among the most visible and frequent mammalian victims of domoic acid poisoning, but rapid, reliable diagnosis in a clinical setting has proved difficult owing to the fast clearance of the toxin from the blood stream. "
07/01/2010 - "Studies in experimental animals suggest that chronic poisoning observed in immature sea lions may result from a spatial and temporal coincidence of DDTs and domoic acid during early life stages. "
03/01/2014 - "Here, we present the concept of domoic acid epileptic disease as a delayed manifestation of domoic acid poisoning and review the state of knowledge for this disease state in affected humans and sea lions. "
08/15/2010 - "However, domoic acid poisoning has a significant effect on marine wildlife and multiple poisoning events have occurred in marine birds and mammals over the last few decades. "
07/01/2010 - "Acute domoic acid poisoning is five-times more prominent in adult female sea lions as a result of the proximity of their year-round breeding grounds to major domoic acid bloom events. "
01/01/2009 - "These studies demonstrate that embryonic exposure to DDTs leads to asymptomatic animals at completion of neurodevelopment with greater sensitivity to domoic acid-induced seizures. "
02/01/1997 - "Results of the present study show that the scratching behaviour, seizure activity, and death, occurred at 12, 40, and 55 min, after intraperitoneal administration of domoic acid at pH 3.7. "
01/01/1990 - "Studies carried out in rats and monkeys revealed that parenterally administered domoic acid induces in rats neuroexcitatory phenomena culminating in seizures. "
11/01/2014 - "California sea lions (CSLs) exposed to the marine biotoxin domoic acid (DA) develop an acute or chronic toxicosis marked by seizures and act as sentinels of the disease. "
03/01/2014 - "Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. "
|3.||Body Weight (Weight, Body)
06/01/1989 - "These studies, preliminary in nature by virtue of the scarcity of domoic acid, gave ip no-effect levels in mice of 0.59 mg/kg body weight based on the behavioural response (scratching) and 2.4 mg/kg for death. "
11/01/1996 - "In a separate experiment, domoic acid at an IP dose of 0.93 mg/kg was found to produce hypomotility in addition to a decrease in body weight. "
01/01/1990 - "Groups of female Sprague-Dawley rats were dosed once intraperitoneally with 0, 1, 2, 4, or 7.5 mg domoic acid/kg of body weight and observed for a maximum period of 24 hr. Clinically, control rats and rats in the 1 mg/kg group were unremarkable. "
06/01/1989 - "Since human intoxication occurred at an estimated 1-5 mg domoic acid/kg body weight, susceptible individuals appear to be more sensitive than rodents to the oral toxicity of domoic acid."
06/01/1989 - "When administered orally doses of between 35 and 70 mg domoic acid/kg body weight were required to produce toxicity in mice and rats. "
07/01/2007 - "A collaborative study was conducted on the Biosense amnesic shellfish poisoning (ASP) enzyme-linked immunosorbent assay (ELISA) for the determination of domoic acid (DA) toxins in shellfish in order to obtain interlaboratory validation data for the method. "
01/01/2005 - "The September 22, 2004 Task Force meeting in St. Louis included discussion of 2 interlaboratory studies, a proprietary kit for domoic acid by enzyme-linked immunosorbent assay (ELISA; Biosense Labs AS, Bergen, Norway) and also a nonproprietary liquid chromatography (LC) method for paralytic shellfish poisoning (PSP) toxins by precolumn oxidation (James F. "
07/01/2015 - "Domoic acid (DA) is a biological neurotoxin that causes amnesic shellfish poisoning. "
01/01/2015 - "The last group of regulated shellfish toxins is the amnesic shellfish poisoning (ASP) toxin domoic acid, produced by species of the genus Pseudo-nitzschia."
01/01/2015 - "Regulations aimed to protect public health from amnesic shellfish poisoning (ASP) are focused on the detection and accurate quantification of domoic acid (DA). "
05/01/2014 - "Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus)."
02/07/2008 - "Two separate clinical syndromes now exist: acute domoic acid toxicosis as has been previously documented, and a second novel neurological syndrome characterized by epilepsy described here associated with chronic consequences of previous sub-lethal exposure to the toxin. "
01/01/2005 - "For the animals injected with domoate that did not develop SE (i.e., those that survived), we could not detect any behavioral signs of spontaneous epileptic seizures in the 6-month observation period, and only minor indications of neuropathologic changes (i.e., neuronal death) over Nissl-stained sections, as well as some small changes in the staining for delta-FosB in a few of the animals. "
01/01/2013 - "In this study, the authors utilized a recently developed rat model for domoic acid-induced epilepsy, an emerging disease appearing in California sea lions weeks to months after poisoning, to identify structural damage that may lead to a permanent epileptic state. "
05/01/2014 - "They develop epilepsy after experiencing status epilepticus when naturally exposed to domoic acid. "
|1.||Kainic Acid (Kainate)
|2.||Glutamic Acid (Glutamate)
|4.||Polychlorinated Biphenyls (PCBs)
|5.||Dichlorodiphenyl Dichloroethylene (DDE)
|6.||Halogenated Diphenyl Ethers
|7.||Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)