domoic acid

Subscribe to Selected New Research on domoic acid

141 relevant articles (0 outcomes, 12 trials/studies) found for this Bio-Agent

Description: kainic acid analog, heterocyclic amino acid from seaweed; RN given refers to parent cpd; structure

Also Known As:

2 alpha-carboxy-4 beta-(5-carboxy-1-methyl-1,3 beta-hexadienyl)-3-pyrrolidineacetic acid; domoate; domoic acid, sodium salt; 3-pyrrolidineacetic acid, 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-, (2S-(2 alpha,3 beta,4 beta(1E,3E,5R*)))-

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Pyrrolidines: 4

Kainic Acid: 2343

domoic acid: 141

Experts

1.	Sawant, Punam M: 1 article (09/2007)
2.	Kerr, D Steven: 1 article (09/2007)
3.	Clarkson, Andrew N: 1 article (09/2007)
4.	Hesp, Blair R: 1 article (09/2007)
5.	Moukha, Serge: 1 article (03/2006)
6.	Carvalho, Pinto-Silva: 1 article (03/2006)
7.	Catian, R: 1 article (03/2006)
8.	Matias, William G: 1 article (03/2006)
9.	Creppy, Edmond E: 1 article (03/2006)
10.	Duarte-Silva, Alexandra: 1 article (08/2005)

Related Diseases

1.	Poisoning 07/01/2007 - "A collaborative study was conducted on the Biosense amnesic shellfish poisoning (ASP) enzyme-linked immunosorbent assay (ELISA) for the determination of domoic acid (DA) toxins in shellfish in order to obtain interlaboratory validation data for the method" 01/01/2005 - "The September 22, 2004 Task Force meeting in St. Louis included discussion of 2 interlaboratory studies, a proprietary kit for domoic acid by enzyme-linked immunosorbent assay (ELISA; Biosense Labs AS, Bergen, Norway) and also a nonproprietary liquid chromatography (LC) method for paralytic shellfish poisoning (PSP) toxins by precolumn oxidation (James F" 01/01/1994 - "An exception to this situation is domoic acid, a neurotoxin phycotoxin that produced numerous cases of severe human intoxication which demanded extensive toxicological study" 06/01/2008 - "Amnesic shellfish poisoning toxin domoic acid (DA) is a marine neurotoxin that accumulates in fish and shellfish, and has been implicated to be involved in human and marine wildlife mortality" 01/01/2008 - "Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans" Order ALL the reference details at left...
2.	Seizures (Seizure) 02/01/1997 - "Results of the present study show that the scratching behaviour, seizure activity, and death, occurred at 12, 40, and 55 min, after intraperitoneal administration of domoic acid at pH 3.7" 01/01/1990 - "Studies carried out in rats and monkeys revealed that parenterally administered domoic acid induces in rats neuroexcitatory phenomena culminating in seizures" 11/01/2007 - "BACKGROUND: Domoic acid (DA) is a neurotoxin produced by diatoms of the genus Pseudo-nitzschia that targets the limbic system to induce tonic-clonic seizures and memory impairment" 09/01/2007 - "Domoic acid preconditioning and seizure induction in young and aged rats." 01/01/2005 - "METHODS: Male and female marmosets (Callithrix jacchus) (n = 18), ages between 2 and 8 years, were injected with domoic acid (0.5-4 mg/kg, i.p.) or saline, and behaviorally assessed with regard to the presence of acutely induced seizures and for < or = 6 months for spontaneous seizures" Order ALL the reference details at left...
3.	Body Weight (Weight, Body) 06/01/1989 - "These studies, preliminary in nature by virtue of the scarcity of domoic acid, gave ip no-effect levels in mice of 0.59 mg/kg body weight based on the behavioural response (scratching) and 2.4 mg/kg for death" 11/11/2008 - "The fish were exposed to three doses of domoic acid (1, 5 and 10 microg/g body weight) by intracoelomic injections" 11/01/1996 - "In a separate experiment, domoic acid at an IP dose of 0.93 mg/kg was found to produce hypomotility in addition to a decrease in body weight" 01/01/1990 - "Groups of female Sprague-Dawley rats were dosed once intraperitoneally with 0, 1, 2, 4, or 7.5 mg domoic acid/kg of body weight and observed for a maximum period of 24 hr. Clinically, control rats and rats in the 1 mg/kg group were unremarkable" 06/01/1989 - "When administered orally doses of between 35 and 70 mg domoic acid/kg body weight were required to produce toxicity in mice and rats" Order ALL the reference details at left...
4.	Syndrome 12/11/1990 - "This preparation provides a good model for examining neurotoxicity and the anterograde amnesic syndrome observed in humans following consumption of domoate-contaminated shellfish." 01/01/1990 - "Mice undergo a typical scratching syndrome at sublethal as well as lethal doses of domoic acid" 02/07/2008 - "Two separate clinical syndromes now exist: acute domoic acid toxicosis as has been previously documented, and a second novel neurological syndrome characterized by epilepsy described here associated with chronic consequences of previous sub-lethal exposure to the toxin" 09/07/2007 - "Domoic acid (DA) is an algal neurotoxin produced by diatoms primarily of the genus Pseudo-nitzschia and is responsible for the human intoxication syndrome known as amnesic shellfish poisoning" 06/22/2007 - "Amnesic shellfish poisoning (ASP) is a potentially lethal human toxic syndrome which is caused by domoic acid (DA) that originates in marine phytoplankton belonging to the Pseudonitzschia genus" Order ALL the reference details at left...
5.	Necrosis 05/01/2008 - "In mouse cerebellar granule neurons (CGNs) the marine neurotoxin domoic acid (DomA) induces neuronal cell death, either by apoptosis or by necrosis, depending on its concentration, with apoptotic damage predominating in response to low concentrations (100 nM)" 12/01/2007 - "CGNs from Gclm (-/-) mice have very low levels of GSH and were more sensitive to domoic acid-induced apoptosis and necrosis than Gclm (+/+) CGNs" 12/01/2007 - "Exposure of mouse cerebellar granule neurons (CGNs) to domoic acid induced cell death, either by apoptosis or by necrosis, depending on its concentration" 04/01/2004 - "The neurotoxic properties of domoic acid result in neuronal degeneration and necrosis in specific regions of the hippocampus" 01/01/1991 - "Domoic acid is contained in mussels which have filter-fed large quantities of domoate-rich phytoplankton, and when contaminated mussels are ingested in large quantities, serious and irreversible CNS effects, accompanied by necrosis, may result" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Kainic Acid (Kainate)
2.	Glutamic Acid (Glutamate)
3.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
4.	Silver
5.	Immunoglobulin G (IgG)
6.	Heat-Shock Proteins (Heat-Shock Protein)
7.	Glucose (Dextrose)
8.	Glial Fibrillary Acidic Protein
9.	fluoro jade
10.	Black-Gold

Related Therapies and Procedures

1.	Intrauterine Devices (Intrauterine Device)

Best Treatments:
Research Summary Report
on Poisoning

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 1036 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>