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2-aminopyrimidine

Also Known As:

aminopyrimidine

Networked: 14 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 2-aminopyrimidine: 14

Experts

1.	Alland, Leila: 2 articles (09/2005 - 07/2005)
2.	Arlinghaus, Ralph B: 2 articles (09/2005 - 07/2005)
3.	Beran, Miloslav: 2 articles (09/2005 - 07/2005)
4.	Cortes, Jorge: 2 articles (09/2005 - 07/2005)
5.	Dugan, Margaret: 2 articles (09/2005 - 07/2005)
6.	Giles, Francis: 2 articles (09/2005 - 07/2005)
7.	Golemovic, Mirna: 2 articles (09/2005 - 07/2005)
8.	Kantarjian, Hagop: 2 articles (09/2005 - 07/2005)
9.	Sun, Tong: 2 articles (09/2005 - 07/2005)
10.	Verstovsek, Srdan: 2 articles (09/2005 - 07/2005)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2013 - "Finally, aminopyrimidine derivatives 33 showed strong tumor growth inhibition against a KPL-4 breast cancer xenograft model in vivo." 01/01/2022 - "Based on our previous studies, we assumed that a hybrid of aminopyrimidine derivatives as EGFR inhibitors and benzocheromen derivatives as cytotoxic agents can induce apoptosis in EGFR positive cancer cells. " 05/12/2011 - "One member of this family, the indole-pyrimidine 4k, having an indole-aryl-substituted aminopyrimidine structure, was observed to be an excellent inhibitor of tubulin polymerization (IC(50) = 0.79 μM) and to display significantly high antiproliferative activities against several cancer cell lines with IC(50) values ranging from 16 to 62 nM. This substance displayed a high propensity to arrests cells at the G(2)/M phase of the cell cycle (EC(50) = 20 nM). "
2.	Pruritus (Itching) 12/01/2018 - "Aim of the present study was to investigate the role of structurally related H4R ligands of the aminopyrimidine class with different efficacies and functionalities (neutral antagonist ST-994, partial agonist ST-1006, inverse agonist ST-1012, and partial inverse agonist ST-1124) on croton oil-induced ear edema and pruritus in mice. "
3.	Ovarian Neoplasms (Ovarian Cancer) 06/24/2023 - "The present study aimed to characterize the antiproliferative and antimetastatic properties of two recently synthesized monoterpene-aminopyrimidine hybrids (1 and 2) on A2780 ovary cancer cells. " 06/24/2023 - "Investigation of Anticancer Properties of Monoterpene-Aminopyrimidine Hybrids on A2780 Ovarian Cancer Cells."
4.	Edema (Dropsy) 12/01/2018 - "Aim of the present study was to investigate the role of structurally related H4R ligands of the aminopyrimidine class with different efficacies and functionalities (neutral antagonist ST-994, partial agonist ST-1006, inverse agonist ST-1012, and partial inverse agonist ST-1124) on croton oil-induced ear edema and pruritus in mice. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2023 - "Design, synthesis and pharmacological characterization of aminopyrimidine derivatives as BTK/FLT3 dual-target inhibitors against acute myeloid leukemia." 01/01/2023 - "2-Aminopyrimidine derivatives as selective dual inhibitors of JAK2 and FLT3 for the treatment of acute myeloid leukemia." 01/01/2023 - "A novel class of aminopyrimidine-based Bruton's tyrosine kinase (BTK) and FMS-like tyrosine kinase 3 (FLT3) dual-target inhibitors based on the BTK inhibitor spebrutinib was designed for the treatment of acute myeloid leukemia. "

Related Drugs and Biologics

1.	Monoterpenes (Monoterpenoids)
2.	Ligands
3.	Cytotoxins (Cytolysins)
4.	Croton Oil
5.	nilotinib
6.	ErbB Receptors (EGF Receptor)
7.	fms-Like Tyrosine Kinase 3
8.	Tubulin
9.	Robenidine
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Oral Administration