nivimedone

inhibits mediator release & capillary permeability; RN given refers to parent cpd

Also Known As:

5,6-dimethyl-2-nitroindane-1,3-dione, sodium salt; BRL 10833; nivimedone sodium; nivimedone, sodium salt, monohydrate; 1H-indene-1,3(2H)-dione, 5,6-dimethyl-2-nitro

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        Indans: 7
        nivimedone: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - Indans: 7
      - nivimedone: 5

Related Diseases

1.	Asthma (Bronchial Asthma) 09/01/1976 - "The ingestion of 2 and 10 mg BRL 10833/kg body weight provides protection against the immediate type allergen induced bronchoconstriction in patients with bronchial asthma. " 07/01/1979 - "The orally administered anti-allergic agent, sodium nivimedone (BRL 10833); efficacy in bronchial asthma and effects on IgE, complement and eosinophils."
2.	Body Weight (Weight, Body) 09/01/1976 - "The ingestion of 2 and 10 mg BRL 10833/kg body weight provides protection against the immediate type allergen induced bronchoconstriction in patients with bronchial asthma. "
3.	Bronchial Spasm 09/01/1976 - "The inhibition of allergen induced bronchospasm in man by oral BRL 10833." 09/01/1976 - "The protective effect of inhaled BRL 10833 on allergen induced bronchospasm." 09/01/1976 - "BRL 10833, a nitroindanedione, with similar inhibitory activities to DSCG on the immediate type IgE mediated hypersensitivity in the rat, has been shown, when inhaled in a dose of 40 mg, to protect against allergen induced bronchospasm. "
4.	Anaphylaxis (Anaphylactic Shock) 09/01/1975 - "A nitroindanedione (BRL 10833) and disodium cromoglycate (DSCG) showed similar activities as inhibitors of IgE-mediated passive cutaneous anaphylaxis (PCA) and passive peritoneal anaphylaxis (PPA) reactions in the rat. " 01/01/1978 - "Passive peritoneal anaphylaxis in rats, sensitized with mouse antiserum, had characteristics of an IgE-mediated reaction, in that the serum was heat-labile and pretreatment of the rats with disodium cromoglycate (DSCG), or sodium nivimedone, inhibited the release of both histamine and slow-reacting substance of anaphylaxis (SRS-A). "
5.	Immediate Hypersensitivity 09/01/1976 - "BRL 10833, a nitroindanedione, with similar inhibitory activities to DSCG on the immediate type IgE mediated hypersensitivity in the rat, has been shown, when inhaled in a dose of 40 mg, to protect against allergen induced bronchospasm. "

Related Drugs and Biologics

1.	Allergens
2.	Immunoglobulin E (IgE)
3.	Sodium
4.	Cromolyn Sodium (Cromoglicic Acid)
5.	nivimedone
6.	Anti-Allergic Agents (Antiallergic Agents)
7.	SRS-A
8.	Histamine (Histamine Dihydrochloride)
9.	Complement System Proteins (Complement)