ASI-222

semisynthetic cardiac glycoside; RN given refers to (3beta,5beta)-isomer; structure

Also Known As:

3 beta-O-(4-amino-4,6-dideoxy-beta-D-galactopyranosyl)digitoxigenin; ASI 222; ASI-222 dihydrate; ASI-222 hydrochloride; (3 beta,5 beta)-3-((4-amino-4,6-dideoxy-beta-D-galactopyranosyl)oxy)-14-hydroxycard-20(22)-enolide

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Cardenolides: 137
        Digitoxin: 364
        Digitoxigenin: 31
        ASI-222: 9

Related Diseases

1.	Cardiotoxicity 06/01/1994 - "The present study examined in vivo and in vitro the effect of halothane on the arrhythmogenicity of ASI-222 (3-beta-O[4-amino-4-6-dideoxy-beta-D-galactopyranosyl] digitoxigen in HCl), a highly polar aminocardenolide with no sympathetic component to cardiotoxicity. " 12/01/1985 - "ASI-222, a highly polar and potent inhibitor of Na+, K+-adenosine triphosphatase produces a cardiotoxicity in dogs prominently involving atrioventricular nodal blockade rather than ventricular premature ectopic beats and tachycardia seen with digoxin. "
2.	Atrioventricular Block 06/01/1994 - "For in vivo studies, ASI-222 was infused at a rate of 1 microgram/kg/min until appearance of third-degree atrioventricular (AV) block or sustained ventricular arrhythmias in 5 conscious (control) and 6 halothane-anesthetized (1.4% end-tidal) dogs. "
3.	Cardiac Arrhythmias (Arrythmia) 04/01/1990 - "Infusion of ASI-222 progressively reduced sympathetic nerve activity (approximately 55%) through the toxic dose; sympathetic nerve activity remained depressed even through the onset of cardiac arrhythmias. " 09/01/1992 - "The vagi were cooled (approximately 4 degrees C) and then either ASI-222 or digoxin was infused i.v. at dose rates which produce cardiac arrhythmias after about 100 min. Saline was infused in a third group. " 01/01/1992 - "After we made baseline measurements, we infused either ASI-222 or digoxin intravenously (i.v.) at dose rates that produce cardiac arrhythmias in approximately 100 min (0.7 and 1.2 micrograms/kg/min), respectively. " 04/01/1990 - "Digoxin or ASI-222 were infused into anesthetized dogs at dose rates which caused cardiac arrhythmias in about 2 hr. Nerve activities were monitored and recorded by a system of differential amplifiers and by a digital storage oscilloscope. " 11/01/1989 - "The effect of i.v. infusion of potassium chloride upon cardiac upon cardiac arrhythmias produced by i.v. infusion of digoxin or ASI-222 in anesthetized dogs was also determined. "
4.	Ventricular Premature Complexes (Premature Ventricular Contraction) 04/01/1976 - "The occurrence of ventricular ectopic beats was observed at a higher cumulative dose of ASI-222 than for ouabain. "
5.	Ventricular Tachycardia 12/01/1978 - "Ventricular tachycardia was elicited at a mean dose of digoxin of 0.12 mg/kg, compared with 0.09 mg/kg for ASI-222 (not significant). "

Related Drugs and Biologics

1.	Halothane (Fluothane)
2.	Digoxin (Digitek)
3.	Potassium Chloride
4.	Ouabain (G Strophanthin)
5.	Metoprolol (Toprol-XL)
6.	Atropine
7.	Adenosine Triphosphatases (ATPase)