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ASI-222
semisynthetic cardiac glycoside; RN given refers to (3beta,5beta)-isomer; structure
Also Known As:
3 beta-O-(4-amino-4,6-dideoxy-beta-D-galactopyranosyl)digitoxigenin; ASI 222; ASI-222 dihydrate; ASI-222 hydrochloride; (3 beta,5 beta)-3-((4-amino-4,6-dideoxy-beta-D-galactopyranosyl)oxy)-14-hydroxycard-20(22)-enolide
Networked:
9
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Cardanolides
Cardiac Glycosides: 1002
Cardenolides: 137
Digitoxin: 364
Digitoxigenin: 31
ASI-222: 9
Related Diseases
1.
Cardiotoxicity
06/01/1994 - "
The present study examined in vivo and in vitro the effect of halothane on the arrhythmogenicity of ASI-222 (3-beta-O[4-amino-4-6-dideoxy-beta-D-galactopyranosyl] digitoxigen in HCl), a highly polar aminocardenolide with no sympathetic component to cardiotoxicity.
"
12/01/1985 - "
ASI-222, a highly polar and potent inhibitor of Na+, K+-adenosine triphosphatase produces a cardiotoxicity in dogs prominently involving atrioventricular nodal blockade rather than ventricular premature ectopic beats and tachycardia seen with digoxin.
"
2.
Atrioventricular Block
06/01/1994 - "
For in vivo studies, ASI-222 was infused at a rate of 1 microgram/kg/min until appearance of third-degree atrioventricular (AV) block or sustained ventricular arrhythmias in 5 conscious (control) and 6 halothane-anesthetized (1.4% end-tidal) dogs.
"
3.
Cardiac Arrhythmias (Arrythmia)
04/01/1990 - "
Infusion of ASI-222 progressively reduced sympathetic nerve activity (approximately 55%) through the toxic dose; sympathetic nerve activity remained depressed even through the onset of cardiac arrhythmias.
"
09/01/1992 - "
The vagi were cooled (approximately 4 degrees C) and then either ASI-222 or digoxin was infused i.v. at dose rates which produce cardiac arrhythmias after about 100 min. Saline was infused in a third group.
"
01/01/1992 - "
After we made baseline measurements, we infused either ASI-222 or digoxin intravenously (i.v.) at dose rates that produce cardiac arrhythmias in approximately 100 min (0.7 and 1.2 micrograms/kg/min), respectively.
"
04/01/1990 - "
Digoxin or ASI-222 were infused into anesthetized dogs at dose rates which caused cardiac arrhythmias in about 2 hr. Nerve activities were monitored and recorded by a system of differential amplifiers and by a digital storage oscilloscope.
"
11/01/1989 - "
The effect of i.v. infusion of potassium chloride upon cardiac upon cardiac arrhythmias produced by i.v. infusion of digoxin or ASI-222 in anesthetized dogs was also determined.
"
4.
Ventricular Premature Complexes (Premature Ventricular Contraction)
04/01/1976 - "
The occurrence of ventricular ectopic beats was observed at a higher cumulative dose of ASI-222 than for ouabain.
"
5.
Ventricular Tachycardia
12/01/1978 - "
Ventricular tachycardia was elicited at a mean dose of digoxin of 0.12 mg/kg, compared with 0.09 mg/kg for ASI-222 (not significant).
"
Related Drugs and Biologics
1.
Halothane (Fluothane)
2.
Digoxin (Digitek)
3.
Potassium Chloride
4.
Ouabain (G Strophanthin)
5.
Metoprolol (Toprol-XL)
6.
Atropine
7.
Adenosine Triphosphatases (ATPase)