prethrombins

removal of profragment 1 from prothrombin leaves prethrombin 1; subsequent removal of profragment 2 leaves prethrombin 2; cleavage of an Arg-Ile bond in prethrombin 2 yields thrombin; RN given refers to cpd with unknown MF

Also Known As:

prethrombin 1; prethrombin 2; Thrombin, pre-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzyme Precursors: 724
  - Prothrombin: 5251
    - prethrombins: 4
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Prothrombin: 5251
        prethrombins: 4
  - Protein Precursors: 37
    - Enzyme Precursors: 724
      - Prothrombin: 5251
        prethrombins: 4
Biological Factors: 2472
- Blood Coagulation Factors: 5376
  - Prothrombin: 5251
    - prethrombins: 4

Experts

1.	Furihata, Mutsuo: 1 article (01/2007)
2.	Iguchi, Mitsuko: 1 article (01/2007)
3.	Kakinuma, Yoshihiko: 1 article (01/2007)
4.	Kudo, Yoshihiro: 1 article (01/2007)
5.	Sato, Takayuki: 1 article (01/2007)
6.	Shuin, Taro: 1 article (01/2007)
7.	Sugiura, Tetsuro: 1 article (01/2007)
8.	Jin, Jong-Youl: 1 article (09/2002)
9.	Kim, Seung-Ho: 1 article (09/2002)
10.	Lee, Jong-Woo: 1 article (09/2002)

Related Diseases

1.	Wounds and Injuries (Trauma) 01/01/2007 - "Thrombin alone did not cause renal injuries; however, thrombin pre-treatment accelerated the development of GN even 1 day after treatment. "
2.	Thrombotic Thrombocytopenic Purpura 09/30/2002 - "Platelet-agglutinating protein p37 from a patient with thrombotic thrombocytopenic purpura has characteristics similar to prethrombin 2."
3.	Hemorrhage 10/15/2001 - "Significant amounts of alpha-thrombin B chain appeared rapidly at 90 seconds of bleeding and increased at a maximum rate of 0.224 +/- 0.03 nM per second to a peak value of 38 nM. Kinetics of prethrombin 2 generation was almost identical. "
4.	Hemophilia B (Haemophilia B) 06/01/1984 - "Neither normal serum nor Factor V deficient serum contain any identifiable Prethrombin 2. On the other hand substantial amounts of Prethrombin 2 are present in Factor IX concentrates used for the treatment of Christmas Disease (Hemophilia B)."

Related Drugs and Biologics

1.	Thrombin
2.	Factor V (Coagulation Factor V)
3.	Factor IX (Coagulation Factor IX)
4.	thrombotic thrombocytopenic purpura platelet agglutinating protein

Related Therapies and Procedures

1.	Aftercare (After-Treatment)