|1.||Ikejima, Takashi: 31 articles (12/2015 - 06/2004)|
|2.||Onodera, Satoshi: 30 articles (12/2015 - 06/2004)|
|3.||Tashiro, Shin-Ichi: 18 articles (12/2015 - 06/2004)|
|4.||Tashiro, Shin-ichi: 12 articles (01/2012 - 10/2004)|
|5.||Qiu, Feng: 6 articles (12/2015 - 03/2009)|
|6.||Xu, Jinyi: 6 articles (07/2014 - 08/2008)|
|7.||Zhou, Jia: 5 articles (12/2015 - 06/2013)|
|8.||Ding, Chunyong: 5 articles (12/2015 - 06/2013)|
|9.||Li, Dahong: 5 articles (07/2014 - 01/2012)|
|10.||Wang, Lei: 5 articles (06/2013 - 08/2008)|
09/01/2014 - "The anti-tumor efficacy of oridonin was dose-dependent and showed strong inhibition of c-Met phosphorylation. "
06/01/2013 - "All target compounds showed improved anti-proliferative activities against four human cancer cell lines compared with natural oridonin and parent compound 10. "
02/06/2015 - "Previous studies with oridonin have demonstrated broad-spectrum anticancer activity in a variety of cancer types. "
01/01/2014 - "This study also provides new evidence supporting the central role of Notch in tumor angiogenesis and suggests that Oridonin could be a potential drug candidate for angiogenesis related diseases. "
11/01/2012 - "Previous studies showed that oridonin inhibits proliferation and induces apoptosis in many tumor cells. "
|2.||Breast Neoplasms (Breast Cancer)
11/14/2013 - "Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis."
01/01/2013 - "To study the mechanisms of inhibition of cell growth and induction of DNA damage in oridonin-treated MCF-7 human breast cancer cells. "
01/01/2013 - "In this study, we investigated the effects of oridonin on growth, migration and invasion of highly-metastatic human breast cancer cells. "
07/01/2007 - "To study the caspase-3-independent mechanisms in oridonin-induced MCF-7 human breast cancer cell apoptosis in vitro. "
01/01/2015 - "Inhibition oridonin phosphate-induced cell autophagy suppressed the progression of cell apoptosis, which revealed that oridonin phosphate-induced autophagy participated in up-regulation of apoptosis in human breast cancer cells. "
|3.||Hepatocellular Carcinoma (Hepatoma)
06/01/2006 - "The present study was undertaken to investigate the mechanisms of oridonin induced apoptosis on human hepatocellular carcinoma BEL-7402 cells. "
01/01/2012 - "These findings demonstrate that oridonin can sensitize hepatocellular carcinoma cells to As2O3 treatment and will facilitate the optimization of As2O3 therapy for HCC patients."
06/01/2011 - "Oridonin has been shown to exhibit therapeutic effects against hepatocellular carcinoma (HCC) in vitro and in vivo. "
06/01/2006 - "The results indicate that oridonin may be an important potential anti-hepatocellular carcinoma reagent."
01/01/2012 - "In this study, we showed that oridonin, a diterpenoid isolated from traditional Chinese medicine Rabdosia rubescences, greatly potentiated apoptosis induced by As2O3 in hepatocellular carcinoma cells. "
|4.||Colorectal Neoplasms (Colorectal Cancer)
04/01/2011 - "Our study confirmed the inhibitory effects of oridonin on colorectal cancer. "
06/01/2007 - "In this study, the anti-proliferation effect of oridonin against the human colorectal carcinoma cells HT29 was investigated both in vitro and in vivo. "
05/01/2015 - "Therefore, these findings suggest that oridonin maybe is a potential candidate for colorectal cancer treatment. "
05/01/2015 - "Oridonin triggers apoptosis in colorectal carcinoma cells and suppression of microRNA-32 expression augments oridonin-mediated apoptotic effects."
02/01/2013 - "These results strengthen the scientific basis for the therapeutic use of oridonin in colorectal cancer."
|5.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/01/2007 - "In this study, we further investigated signaling events involved in oridonin-induced apoptosis in human epidermoid carcinoma A431 cells. "
01/01/2012 - "To further examine the mechanism of oridonin, we selected human epidermoid carcinoma A431 cell as a test object. "
06/25/2010 - "In addition, the generation of reactive oxygen species (ROS) was found to be a critical mediator in growth inhibition induced by 1. Taken together, the results indicate that oridonin (1) is a potentially effective agent for the treatment of laryngeal squamous cell carcinoma."
02/01/2007 - "In this study, we first investigated the mechanism involved in oridonin-induced cell death in human epidermoid carcinoma A431 cells, which overexpress epidermal growth factor receptor (EGFR). "
01/01/2012 - "Hydroxyl radical (·OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells."
|1.||Reactive Oxygen Species (Oxygen Radicals)
|5.||herbal preparation PC-SPES
|7.||Epidermal Growth Factor Receptor (EGF Receptor)
|9.||Cytochromes c (Cytochrome c)
|10.||RNA (Ribonucleic Acid)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|4.||Drug Therapy (Chemotherapy)