melanoidin polymers

polymers consisting mainly of humic & fulvic acids which make up major part of organic carbon reservoir in recent sediments; melanoidins also refer to dark colored substances formed by interaction of reducing sugars & amino acids when heated

Also Known As:

Networked: 22 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dou, Zishan: 2 articles (03/2021 - 11/2020)
2.	Liu, Rui: 2 articles (03/2021 - 11/2020)
3.	Sui, Wenjie: 2 articles (03/2021 - 11/2020)
4.	Wu, Jianfu: 2 articles (03/2021 - 11/2020)
5.	Wu, Tao: 2 articles (03/2021 - 11/2020)
6.	Zhang, Min: 2 articles (03/2021 - 11/2020)
7.	Kandefer-Szerszeń, Martyna: 2 articles (07/2013 - 03/2011)
8.	Langner, Ewa: 2 articles (07/2013 - 03/2011)
9.	Nunes, Fernando M: 2 articles (07/2013 - 03/2011)
10.	Pierzynowski, Stefan G: 2 articles (07/2013 - 03/2011)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 11/09/2011 - "As MMP-1, MMP-2, and MMP-9 play a pivotal role in pathogenesis of colorectal cancer, studies on possible physiological effects of melanoidins are mandatory." 09/01/2012 - "For several years the physiological effects of coffee have been focused on its caffeine content, disregarding the hundreds of bioactive coffee components, such as polyphenols, melanoidins, carbohydrates, diterpenes, etc. These compounds may exert their protection against colorectal cancer (CRC), the third most common cancer worldwide. "
2.	Neoplasms (Cancer) 06/01/2015 - "We conclude by underlining the possible role of food melanoidins in the prevention of gastro-intestinal tract cancers. " 03/23/2011 - "Melanoidins are high molecular weight brown end products of Maillard reaction, and few data presenting tumor cell growth inhibiting activity of melanoidins have been reported. " 12/01/1997 - "Tumor cell growth-inhibiting effect of melanoidins extracted from miso and soy sauce" 01/26/2016 - "We exhibit a wide range of biomedical photonic applications of melanoidins, including in vivo photoacoustic mapping of sentinel lymph nodes, photoacoustic tracking of gastrointestinal tracts, photothermal cancer therapy, and photothermal lipolysis. " 07/01/2013 - "Melanoidins are brown, nitrogen containing, high molecular weight end products of Maillard reaction with poorly established activity towards tumor cells. "
3.	Obesity 11/18/2020 - "Black garlic melanoidins prevent obesity, reduce serum LPS levels and modulate the gut microbiota composition in high-fat diet-induced obese C57BL/6J mice." 11/18/2020 - "The objective of this study is to assess the potential anti-obesity effects of black garlic melanoidins (MLDs) and gut microbiota changes in an animal model, hypothesizing that the effects of oral administration of MLDs can be partially mediated by the modulation of intestinal microbiota via inhibiting the formation of lipopolysaccharides (LPS) and promoting the production of short-chain fatty acids (SCFAs). "
4.	Colonic Neoplasms (Colon Cancer) 07/01/2013 - "The goal of present study was to verify whether both heated potato fiber Potex extract (180°C for 2h) and melanoidins isolated from the extract exerts growth-inhibiting activity in human colon cancer cells in vitro. " 07/01/2013 - "Summarizing, the results emphasize that both high and low molecular weight melanoidins contribute to antiproliferative activity of heated potato fiber in LS180 colon cancer cells in vitro." 07/01/2013 - "The cells of LS180 colon cancer cell line were tested upon treatment with roasted potato fiber extract (AM4) as well as with high (HMW) and low (LMW) molecular weight fractions isolated from the extract, since both may be regarded as/or contain melanoidins. " 07/01/2013 - "Melanoidins isolated from heated potato fiber (Potex) affect human colon cancer cells growth via modulation of cell cycle and proliferation regulatory proteins."
5.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2012 - "Oxidative injury of endothelial cells (ECs) is the key step for the onset and progression of cardiovascular diseases (CVD), therefore the potential protective effect of apricot melanoidins on hydrogen peroxide-induced oxidative mitochondrial damage and cell death was explored in human ECs. " 01/01/2011 - "Oxidative-induced endothelial cell (EC) damage is the trigger for the development of cardiovascular diseases (CVD); therefore the potential protective effect of prune melanoidins on hydrogen peroxide-induced oxidative cell damage was investigated on human endothelial ECV304 cells. " 01/01/2021 - "Free radicals are villainous substances in humans produced as metabolic byproducts and causing cancers and cardiovascular diseases, and the melanoidins alleviate the effects of these free radicals. "

Related Drugs and Biologics

1.	Coffee
2.	Polyphenols
3.	Diterpenes
4.	Carbohydrates
5.	Caffeine (No Doz)
6.	Lipopolysaccharides
7.	Volatile Fatty Acids
8.	Hydrogen Peroxide (Hydroperoxide)
9.	Sirtuin 3
10.	Sirtuin 1

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics