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alpha-chaconine

glycoside of solanidine; structure in 5th source

Also Known As:

conine

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lee, Kap-Rang: 3 articles (06/2006 - 05/2004)
2.	Friedman, Mendel: 3 articles (07/2005 - 01/2003)
3.	Chen, Pin-Shern: 2 articles (01/2010 - 12/2007)
4.	Shih, Yuan-Wei: 2 articles (01/2010 - 12/2007)
5.	Kozukue, Nobuyuki: 2 articles (06/2006 - 05/2004)
6.	Chang, Ya-Ting: 1 article (01/2010)
7.	Chen, Pei-Hsieng: 1 article (01/2010)
8.	Huang, En-Tze: 1 article (01/2010)
9.	Liu, Cheng-Ruei: 1 article (01/2010)
10.	Lu, Ming-Kun: 1 article (01/2010)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 12/26/2007 - "Inhibiting metastasis by alpha-chaconine might offer a pivotal mechanism for its effective chemotherapeutic action." 12/26/2007 - "The aim of this study is to investigate the inhibitory effect of alpha-chaconine on lung adenocarcinoma cell metastasis in vitro. " 12/26/2007 - "Alpha-chaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-kappaB in human lung adenocarcinoma A549 cells." 12/26/2007 - "These results suggested that alpha-chaconine inhibited A549 cell metastasis by a reduction of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) activities involving suppression of phosphoinositide 3-kinase/Akt/NF-kappaB (PI3K/Akt/NF-kappaB) signaling pathway. "
2.	Adenocarcinoma of Lung 12/26/2007 - "The aim of this study is to investigate the inhibitory effect of alpha-chaconine on lung adenocarcinoma cell metastasis in vitro. " 12/26/2007 - "Alpha-chaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-kappaB in human lung adenocarcinoma A549 cells."
3.	Neoplasms (Cancer) 01/01/2010 - "However, the effect of alpha-chaconine on tumor angiogenesis remains unclear. " 01/01/2010 - "alpha-Chaconine, a naturally occurring steroidal glycoalkaloid in potato sprouts, was found to possess anti-carcinogenic properties, such as inhibiting proliferation, migration, invasion, and inducing apoptosis of tumor cells. " 06/01/2006 - "Although alpha-chaconine, one of the two major potato trisaccharide glycoalkaloids, have shown cytotoxic effects on human cancer cells, the exact mechanism of this action of alpha-chaconine is not completely understood. " 07/27/2005 - "The results show that (a) the effects of the glycoalkaloids were concentration dependent in the range of 0.1-10 mug/mL (0.117-11.7 nmol/mL); (b) alpha-chaconine was more active than was alpha-solanine; (c) some mixtures exhibited synergistic effects, whereas other produced additive ones; (d) the different cancer cells varied in their susceptibilities to destruction; and (e) the destruction of normal liver cells was generally lower than that of cancer liver cells. "
4.	Body Weight (Weight, Body) 06/01/2009 - "Doses of up to 33.3 mg total glycoalkaloids/kg body weight were applied in ratios of 1:3.7 and 1:70 (alpha-solanine:alpha-chaconine). " 05/01/1996 - "A mixture of alpha-solanine and alpha-chaconine (1:1, w/w) given orally at doses of up to 50 mg/kg body weight to hamsters had no effect, but a single ip injection of 25 mg/kg body weight or greater was lethal, with bleeding in the gut. " 08/01/1991 - "Elevated activities persisted for several hours, decreasing to about one-third of the maximal level at 8 hr. The relative effects of alpha-solanine, alpha-chaconine and solanidine on ODC activities were studied at 4 hr using an equimolar dose of 17 mM/kg body weight. "
5.	Poisoning 05/01/1996 - "Eating green potatoes has reportedly led to poisoning attributed to potato glycoalkaloids (PGA), primarily alpha-solanine and alpha-chaconine. " 01/01/1991 - "These findings support the hypothesis that the alkaloid-evoked Ca(2+) influx is caused by destabilization of the cell membrane and attribute a more important role to alpha-chaconine than alpha-solanine in potato poisoning. "

Related Drugs and Biologics

1.	alpha-solanine
2.	solanidine
3.	Alkaloids
4.	alpha-tomatine
5.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
6.	Caspase 3 (Caspase-3)
7.	Matrix Metalloproteinase 9 (Gelatinase B)
8.	Matrix Metalloproteinase 2 (Gelatinase A)
9.	NF-kappa B (NF-kB)
10.	Fura-2 (Fura 2)

Related Therapies and Procedures

1.	Oral Administration