|1.||Lee, Kap-Rang: 3 articles (06/2006 - 05/2004)|
|2.||Friedman, Mendel: 3 articles (07/2005 - 01/2003)|
|3.||Shih, Yuan-Wei: 2 articles (01/2010 - 12/2007)|
|4.||Chen, Pin-Shern: 2 articles (01/2010 - 12/2007)|
|5.||Kozukue, Nobuyuki: 2 articles (06/2006 - 05/2004)|
|6.||Liu, Cheng-Ruei: 1 article (01/2010)|
|7.||Safe, Stephen H: 1 article (01/2010)|
|8.||Miller, J Creighton: 1 article (01/2010)|
|9.||Chang, Ya-Ting: 1 article (01/2010)|
|10.||Huang, En-Tze: 1 article (01/2010)|
|1.||Neoplasm Metastasis (Metastasis)
12/26/2007 - "Inhibiting metastasis by alpha-chaconine might offer a pivotal mechanism for its effective chemotherapeutic action."
12/26/2007 - "The aim of this study is to investigate the inhibitory effect of alpha-chaconine on lung adenocarcinoma cell metastasis in vitro. "
12/26/2007 - "Alpha-chaconine-reduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-kappaB in human lung adenocarcinoma A549 cells."
12/26/2007 - "These results suggested that alpha-chaconine inhibited A549 cell metastasis by a reduction of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) activities involving suppression of phosphoinositide 3-kinase/Akt/NF-kappaB (PI3K/Akt/NF-kappaB) signaling pathway. "
01/01/2010 - "However, the effect of alpha-chaconine on tumor angiogenesis remains unclear. "
01/01/2010 - "alpha-Chaconine, a naturally occurring steroidal glycoalkaloid in potato sprouts, was found to possess anti-carcinogenic properties, such as inhibiting proliferation, migration, invasion, and inducing apoptosis of tumor cells. "
06/01/2006 - "Although alpha-chaconine, one of the two major potato trisaccharide glycoalkaloids, have shown cytotoxic effects on human cancer cells, the exact mechanism of this action of alpha-chaconine is not completely understood. "
07/27/2005 - "The results show that (a) the effects of the glycoalkaloids were concentration dependent in the range of 0.1-10 mug/mL (0.117-11.7 nmol/mL); (b) alpha-chaconine was more active than was alpha-solanine; (c) some mixtures exhibited synergistic effects, whereas other produced additive ones; (d) the different cancer cells varied in their susceptibilities to destruction; and (e) the destruction of normal liver cells was generally lower than that of cancer liver cells. "
|3.||Body Weight (Weight, Body)
06/01/2009 - "Doses of up to 33.3 mg total glycoalkaloids/kg body weight were applied in ratios of 1:3.7 and 1:70 (alpha-solanine:alpha-chaconine). "
05/01/1996 - "A mixture of alpha-solanine and alpha-chaconine (1:1, w/w) given orally at doses of up to 50 mg/kg body weight to hamsters had no effect, but a single ip injection of 25 mg/kg body weight or greater was lethal, with bleeding in the gut. "
08/01/1991 - "Elevated activities persisted for several hours, decreasing to about one-third of the maximal level at 8 hr. The relative effects of alpha-solanine, alpha-chaconine and solanidine on ODC activities were studied at 4 hr using an equimolar dose of 17 mM/kg body weight. "
01/01/1991 - "These findings support the hypothesis that the alkaloid-evoked Ca(2+) influx is caused by destabilization of the cell membrane and attribute a more important role to alpha-chaconine than alpha-solanine in potato poisoning. "
05/01/1996 - "Eating green potatoes has reportedly led to poisoning attributed to potato glycoalkaloids (PGA), primarily alpha-solanine and alpha-chaconine. "
|5.||Prostatic Neoplasms (Prostate Cancer)
01/01/2010 - "These results suggest that apoptosis induced by whole potato extracts in prostate cancer cell lines may be in part due to alpha-chaconine and gallic acid."
01/01/2010 - "The bioactive compounds alpha-chaconine and gallic acid in potato extracts decrease survival and induce apoptosis in LNCaP and PC3 prostate cancer cells."
|1.||Adenocarcinoma of lung
|5.||Caspase 3 (Caspase-3)
|6.||Matrix Metalloproteinase 9 (Gelatinase B)
|7.||Matrix Metalloproteinase 2 (Gelatinase A)
|8.||NF-kappa B (NF-kB)
|9.||Fura-2 (Fura 2)