ethylenediamine- N,N'- bis(2- hydroxyphenylacetic acid)

synthetic iron chelator; RN given refers to parent cpd; structure in 3rd source

Also Known As:

EDBHA; EDBPHA; EDDHA; EHPG; N,N'-ethylenebis(o-hydroxyphenyl)glycine; ethylenediamine-N,N'-bis(2-hydroxyphenyl)glycine; ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid), dihydrochloride; ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid), disodium salt; ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid), iron (+3) salt; ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid), iron, sodium salt; ethylenediaminedi-o-hydroxyphenylacetic acid; benzeneacetic acid, alpha,alpha'-(1,2-ethanediylimino)bis(2-hydroxy)-

Networked: 19 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Ethylenediamines: 7
        ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid): 19

Experts

1.	Lucena, Juan J: 7 articles (01/2019 - 01/2002)
2.	Sierra, Miguel A: 5 articles (07/2010 - 01/2002)
3.	Gómez-Gallego, Mar: 4 articles (07/2010 - 10/2002)
4.	López-Rayo, Sandra: 3 articles (01/2019 - 09/2009)
5.	García-Marco, Sonia: 3 articles (02/2006 - 10/2002)
6.	Hernández, Diana: 2 articles (07/2010 - 09/2009)
7.	Alcázar, Roberto: 2 articles (08/2003 - 10/2002)
8.	Yunta, Felipe: 2 articles (08/2003 - 10/2002)
9.	Agüera, Ana: 1 article (09/2021)
10.	Malato, Sixto: 1 article (09/2021)

Related Diseases

1.	Hypochromic Anemia (Chlorosis) 01/18/2017 - "The three o,o-EDDHA/Fe3+ formulations tested were effective in preventing iron chlorosis in healthy plants. " 03/22/2013 - "EDDHSA/Fe is a promising substitute of EDDHA/Fe to fight iron chlorosis. " 09/23/2009 - "A new chelating agent, HJB (N,N'-bis(2-hydroxy-5-methylphenyl)ethylendiamine-N,N'-diacetic acid) may be an alternative to o,o-EDDHA since its synthesis yields a purer product, but its chemical behavior and efficiency as chlorosis corrector should be evaluated. " 02/22/2006 - "EDDHA/Fe3+ chelates are the most common fertilizers used to solve Fe chlorosis in established crops. " 10/07/2005 - "Understanding of the mode of action of Fe(III)-EDDHA as iron chlorosis corrector based on its photochemical and redox behavior."
2.	Iron Deficiencies 01/10/2019 - "Iron deficiency in crops is usually prevented and cured by the application of synthetic Fe chelates such as EDTA/Fe and the o,o-EDDHA/Fe. " 01/18/2017 - "Two o,o-EDDHA/Fe3+ formulations (meso, 93.5% w/w of meso isomer; and d,l-racemic, 91.3% w/w of d,l-racemic mixture) were prepared, and their efficacy to avoid or to relieve iron deficiency in Fe-sufficient and Fe-deficient tomato plants grown on hydroponic solution was compared with that of the current o,o-EDDHA/Fe3+ formulations (50% of meso and d,l-racemic isomers). "
3.	Sarcoma (Soft Tissue Sarcoma) 01/01/1988 - "Intravenous injection of the gallium chelating agents, N,N'-ethylene bis[2-hydroxy-5-carboxyphenyl-glycine], (COOH-EHPG), or desferrioxamine (DFO) after gallium-67 (67Ga) injection, improved tumour/non-tumour tissue uptake ratios in mice bearing the EMT-6 sarcoma. "
4.	Hemochromatosis (Bronze Diabetes) 05/01/1980 - "The use of EDBPHA as a potential iron chelator in cases of hemochromatosis provided impetus for investigating its toxicology. "
5.	Biliary Atresia 01/01/1988 - "Potential radiopharmaceuticals for the diagnosis of biliary atresia and neonatal hepatitis: EHPG and HBED chelates of 67Ga and 111In."

Related Drugs and Biologics

1.	Edetic Acid (EDTA)
2.	Chelating Agents
3.	Iron
4.	Glycine (Aminoacetic Acid)
5.	Gallium
6.	Deferoxamine (Desferal)
7.	ethylene
8.	Gallium-67
9.	Soil
10.	Heavy Metals

Related Therapies and Procedures

1.	Intravenous Injections
2.	Transjugular Intrahepatic Portasystemic Shunt
3.	Induced Hyperthermia (Thermotherapy)