dicyclohexylamine

potent inhibitor of spermidine synthase; RN given refers to parent cpd

Also Known As:

cyclohexanamine, N-cyclohexyl-, sulfate (1:1); dicyclohexylamine hydrochloride; dicyclohexylamine nitrate; dicyclohexylamine nitrite; dicyclohexylamine phosphate (3:1); dicyclohexylamine sulfate; dicyclohexylamine sulfate (1:1); dicyclohexylammonium

Networked: 12 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Cyclohexylamines: 33
    - dicyclohexylamine: 12
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexylamines: 33
        dicyclohexylamine: 12

Experts

1.	Stanimirovic, Zoran: 2 articles (10/2008 - 03/2007)
2.	Stevanovic, Jevrosima: 2 articles (10/2008 - 03/2007)
3.	Alberoni, D: 1 article (02/2016)
4.	Baffoni, L: 1 article (02/2016)
5.	Biavati, B: 1 article (02/2016)
6.	Cabbri, R: 1 article (02/2016)
7.	Di Gioia, D: 1 article (02/2016)
8.	Gaggìa, F: 1 article (02/2016)
9.	Nanetti, A: 1 article (02/2016)
10.	Chen, Jian-Ping: 1 article (04/2011)

Related Diseases

1.	Chromosome Aberrations (Chromosome Abnormalities) 03/30/2007 - "In this study, the genotoxicity of fumagillin (in the form of fumagillin dicyclohexylamine) was evaluated in mouse bone-marrow cells using the mitotic index (MI), the chromosome aberration (CA) assay, and the micronucleus (MN) test. " 10/01/2008 - "The aim of the present study was to investigate and explain the clastogenic effects of fumagillin (in the form of fumagillin dicyclohexylamine salt) on human peripheral blood lymphocytes in vitro by sister-chromatid exchanges (SCE), chromosome aberrations (CA), and micronucleus (MN) tests. "
2.	Neoplasms (Cancer) 04/25/2011 - "The dicyclohexylammonium salt of hyperforin (DCHA-HF) has exhibited antitumor and antiangiogenic activities in various cancer cells. " 09/01/2004 - "Hyperforin (Hyp), the major lipophilic constituent of St. John's wort, was assayed as a stable dicyclohexylammonium salt (Hyp-DCHA) for cytotoxicity and inhibition of matrix proteinases, tumor invasion, and metastasis. "
3.	Trypanosomiasis 09/01/1984 - "Administration of dicyclohexylamine to mice with trypanosomiasis resulted in no increase in survival time probably due to the lack of effect on trypanosome spermidine concentrations. "
4.	Neoplasm Metastasis (Metastasis) 09/01/2004 - "Hyperforin (Hyp), the major lipophilic constituent of St. John's wort, was assayed as a stable dicyclohexylammonium salt (Hyp-DCHA) for cytotoxicity and inhibition of matrix proteinases, tumor invasion, and metastasis. "
5.	Mastitis 11/01/1984 - "The effect of dicyclohexylamine on seven freshly isolated bacterial strains of mastitis pathogens was studied. "

Related Drugs and Biologics

1.	fumagillin
2.	Salts
3.	Spermidine Synthase
4.	hyperforin
5.	Sulfates (Sulfates, Inorganic)
6.	Polyamines
7.	Substance P
8.	Spermidine
9.	Peptide Hydrolases (Proteases)