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4,4'-thiodianiline
structure
Also Known As:
4,4'-diaminodiphenylsulfide
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Aniline Compounds: 46
4,4'-thiodianiline: 2
Related Diseases
1.
Body Weight (Weight, Body)
01/01/1978 - "
The administration of 4,4'-thiodianiline resulted in marked reduction in mean body weights of the rats and mice of each sex, and all dosed animals died prior to the scheduled end of the study.
"
2.
Neoplasms (Cancer)
01/01/1978 - "
4,4'-Thiodianiline was carcinogenic for B6C3F1 mice, inducing tumors in the liver and thyroid of both males and females.
"
01/01/1978 - "
It is concluded that under the conditions of this bioassay, 4,4'-thiodianiline was carcinogenic for Fischer 344 rats, inducing tumors in the liver, thyroid, colon, and ear canal of male rats, and the thyroid, uterus, and ear canal of female rats.
"
01/01/1978 - "
This incidence is not statistically significant; however, no such tumors occurred among the 235 historical-control male rats at this laboratory; thus, the tumors of the colon are considered to be related to administration of 4,4'-thiodianiline.
"
08/01/1991 - "
Synergistic enhancement of thyroid tumor induction by 2,4-diaminoanisole sulfate, N,N'-diethylthiourea and 4,4'-thiodianiline in male F344 rats.
"
Related Drugs and Biologics
1.
diethylthiourea
2.
4-methoxy-3-phenylenediamine