cholest-5-en-3 beta,7 alpha-diol

substrate for hydroxysteroid dehydrogenase; RN given refers to (3beta,7alpha)-isomer

Also Known As:

7 alpha-hydroxycholesterol; 7 beta-hydroxycholesterol; 7alpha-hydroxycholesterol; 7beta-hydroxycholesterol; cholest-5-en-3 beta,7 alpha-diol, (3beta)-isomer; cholest-5-en-3 beta,7 alpha-diol, (3beta,7alpha)-isomer, 14C-labeled; cholest-5-en-3 beta,7 alpha-diol, (3beta,7beta)-isomer; cholest-5-en-3beta,7beta-diol

Networked: 72 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Wei: 3 articles (01/2009 - 10/2005)
2.	Yuan, Xi-Ming: 3 articles (01/2009 - 10/2005)
3.	Lemaire-Ewing, Stéphanie: 3 articles (01/2005 - 08/2002)
4.	Lizard, Gérard: 3 articles (01/2005 - 08/2002)
5.	Néel, Dominique: 3 articles (01/2005 - 08/2002)
6.	Prunet, Céline: 3 articles (01/2005 - 08/2002)
7.	Lütjohann, Dieter: 2 articles (01/2020 - 09/2004)
8.	Caruso, Donatella: 2 articles (09/2008 - 07/2007)
9.	Crosignani, Andrea: 2 articles (09/2008 - 07/2007)
10.	De Fabiani, Emma: 2 articles (09/2008 - 07/2007)

Related Diseases

1.	Gliosis 01/01/2006 - "7beta-Hydroxycholesterol has been previously demonstrated to inhibit astrocytosis in injured cortex or spinal cord of rats. " 12/01/1992 - "7 beta-hydroxycholesterol and 7 beta-hydroxycholesteryl-3-esters reduce the extent of reactive gliosis caused by an electrolytic lesion in rat brain." 10/01/2000 - "We have shown previously that 7beta-hydroxycholesterol (7betaOHCH) and 7beta-hydroxycholesteryl-3-oleate (7betaOHCH- 3-OL) are potent inhibitors of lesion-induced astrogliosis in the rat cortex or spinal cord; these substances reduce reactive astrocyte proliferation and hypertrophy. " 12/01/1992 - "These findings, which demonstrate anti-proliferative and anti-inflammatory properties of 7 beta-hydroxycholesterol on astrocytes, facilitate the future investigation of the influence of reactive gliosis on functional recovery following brain injury. " 03/01/1998 - "LCM were assessed as a delivery vehicle for 7beta-hydroxycholesterol in a rat brain radiofrequency lesion and found to be efficient in reducing astrogliosis, as measured by glial fibrillary acidic protein immunoreactivity."
2.	Atherosclerosis 04/11/2003 - "This finding supports the theory that 7 beta-hydroxycholesterol and 7-ketocholesterol could induce cytotoxic and oxidative processes observed in atherosclerotic lesions and that esterification of these compounds may contribute to reducing atherosclerosis progression." 08/01/2002 - "Among oxysterols oxidized at C7 (7alpha-, 7beta-hydroxycholesterol, and 7-ketocholesterol) 7beta-hydroxycholesterol and 7-ketocholesterol are potent inducers of cell death and probably play central roles in atherosclerosis. " 09/01/2007 - "These two oxysterols are formed as a result of low density lipoprotein oxidation and in a study on biomarkers for oxidative stress in patients with atherosclerosis, 7beta-hydroxycholesterol was found to be the strongest predictor of progression of carotid atherosclerosis. " 07/01/2008 - "Since atherosclerosis is associated with the presence of apoptotic cells and with oxidative and inflammatory processes, the ability of some oxysterols, especially 7-ketocholesterol and 7beta-hydroxycholesterol, to trigger cell death, activate inflammation, and modulate lipid homeostasis is being extensively studied, especially in vitro. " 02/01/2006 - "Therefore, 7beta- as well as 7alpha-hydroxycholesterol could be more appropriate markers of lipid metabolism disorders than cholesterol or LDL in normocholesterolemic patients with atherosclerosis of the lower limbs, and statins could normalize their serum concentrations. "
3.	Atherosclerotic Plaque (Atheroma) 10/01/2005 - "Foam cell death induced by 7beta-hydroxycholesterol is mediated by labile iron-driven oxidative injury: mechanisms underlying induction of ferritin in human atheroma." 01/01/2005 - "On treatment with 7-ketocholesterol (7-keto) or 7beta-hydroxycholesterol (7beta-OH), which are major oxysterols in atherosclerotic plaques, the simultaneous identification of oncotic and apoptotic cells suggests that these compounds activate different metabolic pathways leading to various modes of cell death. " 09/15/2006 - "In the present study, we investigated the cytotoxic effects of 7beta-hydroxycholesterol (7betaOH), 7-ketocholesterol (7keto), 25-hydroxycholesterol (25OH), and 27-hydroxycholesterol (27OH) on U937 monocytic cells, both individually and in atheroma-relevant mixtures mimicking the oxysterol composition reported in human atheroma lesions. " 03/01/2007 - "As products of cholesterol oxidation (oxysterols) accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery, we investigated the potential of 7-ketocholesterol (7-KC), 7beta-hydroxycholesterol (7beta-HC) and 25-hydroxycholesterol (25-HC) to stimulate inflammatory signalling via the lipid-recognising TLRs 1, 2, 4 and 6. Each oxysterol stimulated secretion of the inflammatory chemokine interleukin-8 (IL-8), but not IkappaBalpha degradation or tumour necrosis factor-alpha release from monocytic THP-1 cells. "
4.	Colonic Neoplasms (Colon Cancer) 02/01/2005 - "Our study aimed at comparing antiproliferative effects of 7beta-hydroxysitosterol (7beta-OHsito) versus 7beta-hydroxycholesterol (7beta-OHchol) on the human colon cancer cell line Caco-2. " 01/01/2007 - "Mitochondrial perturbation, oxidative stress and lysosomal destabilization are involved in 7beta-hydroxysitosterol and 7beta-hydroxycholesterol triggered apoptosis in human colon cancer cells." 02/01/2005 - "Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells." 12/01/2006 - "Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol."
5.	Lung Neoplasms (Lung Cancer) 08/01/2005 - "The cytotoxic activity of 7beta-hydroxycholesterol (7beta-OHC) was evaluated on human NCI-H460 lung cancer cells. " 08/01/2005 - "Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells." 12/01/2002 - "Among all COP compounds tested, plasma 7beta-hydroxycholesterol was associated with lung cancer risk. " 12/01/2002 - "Plasma 7beta-hydroxycholesterol as a possible predictor of lung cancer risk." 12/01/2002 - "In this small study, plasma 7beta-hydroxycholesterol appeared to be a smoking-independent predictor of lung cancer risk and might therefore be used as a biomarker. "

Related Drugs and Biologics

1.	Oxysterols
2.	7-ketocholesterol
3.	Biomarkers (Surrogate Marker)
4.	25-hydroxycholesterol
5.	27-hydroxycholesterol
6.	Liposomes (Liposome)
7.	Iron
8.	7-hydroxycholesteryl-3-oleate
9.	Phosphotransferases (Kinase)
10.	LDL Lipoproteins (beta Lipoproteins)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics