lysolecithin acylhydrolase

a lysophospholipase expressed in eosinophils and basophils; It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid; It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins

Also Known As:

Networked: 20 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Chengshuo: 2 articles (01/2021 - 01/2020)
2.	Wang, Yang: 2 articles (01/2021 - 01/2020)
3.	Yan, Bing: 2 articles (01/2021 - 01/2020)
4.	Zhang, Luo: 2 articles (01/2021 - 01/2020)
5.	Su, Jiyong: 2 articles (01/2019 - 11/2018)
6.	Cassano, Michele: 1 article (03/2022)
7.	Fiore, Valeria: 1 article (03/2022)
8.	Gelardi, Matteo: 1 article (03/2022)
9.	Giancaspro, Rossana: 1 article (03/2022)
10.	Grilli, Gianluigi Mariano: 1 article (03/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2019 - "Galectin-10 is a major constituent of human eosinophils, also known as the Charcot-Leyden crystal protein, which has been linked with eosinophilic inflammation. " 03/01/2022 - "Several biomarkers of eosinophilic inflammation, including Galectin-10, also known as Charcot-Leyden crystal protein (CLCP), have been identified to establish eosinophilic infiltration of polyps, a reliable predictor of recurrence.Objective" 01/15/1993 - "We have isolated and sequenced a 598-bp full length cDNA clone for the human Charcot-Leyden crystal (CLC) protein (eosinophil lysophospholipase), the unique and prominent constituent of human eosinophils and basophils that forms the hexagonal bipyramidal crystals classically observed in tissues and secretions from sites of eosinophil-associated inflammation. " 01/01/2019 - "Charcot-Leyden crystal protein/galectin-10 is a surrogate biomarker of eosinophilic airway inflammation in asthma."
2.	Hypersensitivity (Allergy) 07/01/2004 - "These bipyramidal-shaped crystals are composed of the enzyme lysolecithin acylhydrolase, one of several eosinophilic proteins that damage respiratory epithelium and contribute to the pathology of allergy in the upper respiratory tract." 11/09/2018 - "The significant presence of eosinophils in these tissues are associated with various diseases, including asthma, allergies, acute myeloid leukemia, etc. Charcot-Leyden crystal protein/galectin-10 is overexpressed in eosinophils and has also been identified in basophils and macrophages. " 02/01/2006 - "One previously unidentified NLF protein was found in all samples from the SAR patients during allergy season but not in any sample before allergy season: this protein was identified as eosinophil lysophospholipase (Charcot-Leyden crystal protein/galactin 10). "
3.	Neoplasms (Cancer) 05/01/1990 - "These findings provide evidence that epithelial tumor cells contain Charcot-Leyden crystal protein that most likely originates from tumor stroma eosinophils. " 05/01/1996 - "Vesicular transport of Charcot-Leyden crystal protein in tumor-promoting phorbol diester-stimulated human basophils." 05/01/1990 - "Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas."
4.	Nasal Polyps (Nasal Polyp) 01/01/2021 - "Predictive Significance of Charcot-Leyden Crystal Protein in Nasal Secretions in Recurrent Chronic Rhinosinusitis with Nasal Polyps." 10/01/2017 - "Gene expression of the eosinophil marker CLC (Charcot Leyden crystal protein) was elevated in superior turbinate (ST) tissue in chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) compared to ST and inferior turbinate tissue in CRS without nasal polyps (CRSsNP) and control patients (all P < 0.001, respectively). "
5.	Eosinophilia 01/01/2020 - "Charcot-Leyden Crystal Protein in Nasal Secretions of Patients with Nonallergic Rhinitis with Eosinophilia Syndrome." 09/01/1981 - "Eosinophilia and elevated serum levels of eosinophil major basic protein and Charcot-Leyden crystal protein (lysophospholipase) after treatment of patients with Bancroft's filariasis."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Lysophospholipase (Phospholipase B)
3.	Eosinophil Major Basic Protein
4.	Galectins (Galectin)
5.	Biomarkers (Surrogate Marker)
6.	Enzymes
7.	lysolecithin acylhydrolase
8.	Stem Cell Factor
9.	Complementary DNA (cDNA)
10.	Interleukin-4 (Interleukin 4)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)