|1.||Mustafa, Mohd Rais: 4 articles (06/2015 - 01/2012)|
|2.||Murugan, Dharmani: 3 articles (06/2015 - 01/2012)|
|3.||Gerhardt, Daniéli: 2 articles (01/2014 - 12/2009)|
|4.||Achike, Francis I: 2 articles (02/2013 - 01/2012)|
|5.||Salbego, Christianne: 2 articles (12/2009 - 11/2008)|
|6.||Lau, Yeh Siiang: 1 article (06/2015)|
|7.||Ling, Wei Chih: 1 article (06/2015)|
|8.||Ceckova, Martina: 1 article (05/2015)|
|9.||Staud, Frantisek: 1 article (05/2015)|
|10.||Nachtigal, Petr: 1 article (05/2015)|
|1.||Hypertension (High Blood Pressure)
06/01/2015 - "Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes."
01/01/2012 - "In the present study, we investigated the effects of boldine on endothelial dysfunction in hypertension using spontaneously hypertensive rats (SHR), the most studied animal model of hypertension. "
06/01/2015 - "The present review supports a complimentary therapeutic role of the phytochemical, boldine, against endothelial dysfunctions associated with hypertension and diabetes mellitus by interfering with the oxidative stress-mediated signaling pathway. "
06/01/2015 - "Boldine exhibited significant endothelial protective effect in animal models of hypertension and diabetes mellitus. "
01/01/2012 - "These results show that boldine treatment exerts endothelial protective effects in hypertension, achieved, at least in part, through the inhibition of NADPH-mediated superoxide production."
|3.||Cardiovascular Diseases (Cardiovascular Disease)
04/25/2015 - "This study suggests that derivatives of boldine could be potent anti-cancer drugs. "
12/01/2009 - "Based on these results, we speculate that boldine may be a promising compound for evaluation as an anti-cancer agent."
12/01/2009 - "Boldine had no toxic effect on non-tumor cells when used at the same concentrations as those used on tumor cells. "
05/01/1994 - "In tumor-bearing patients, LDCC activity was strongly enhanced by higher concentrations of boldine, whereas NCMC activity changed significantly only at the concentration of 1.0 microgram/ml."
04/25/2015 - "This study advocates boldine as a valuable candidate for telomerase-targeted cancer care. "
|5.||Breast Neoplasms (Breast Cancer)
01/01/2014 - "In this study, we found that boldine potently inhibited the viability of the human invasive breast cancer cell lines, MDA-MB-231 (48-hour IC₅₀ 46.5±3.1 μg/mL) and MDA-MB-468 (48-hour IC₅₀ 50.8±2.7 μg/mL). "
01/01/2014 - "Our results suggest that boldine is a potentially useful agent for the treatment of breast cancer."
01/01/2014 - "Evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models."
05/01/1994 - "The in vitro effects of boldine on natural killer (NK) cells, lectin-dependent cell-mediated cytotoxicity (LDCC) and lectin-induced blast transformation were studied in patients with breast cancer, chronic lymphocytic leukemia (CLL) and healthy donors. "
04/25/2015 - "Cytotoxicity of boldine in human fibroblasts was considerably lower than the telomerase positive embryonic kidney HEK293 and breast cancer MCF-7 and MDA-MB-231 cells. "
|5.||Telomerase (Telomerase Reverse Transcriptase)
|2.||Induced Hyperthermia (Thermotherapy)