apramycin

11/01/2021 - "A combination of data-base mining, antimicrobial susceptibility testing, time-kill experiments, and four murine infection models was used in a comprehensive assessment of the microbiological coverage and efficacy of EBL-1003 against Gram-negative uropathogens. "
11/01/2014 - "In vivo efficacy of apramycin in murine infection models."
01/01/1987 - "Evaluation of the efficacy of apramycin against Salmonella pullorum infection in chickens."
10/01/2022 - "In this study, we characterized the preclinical pharmacokinetics (PK) and pharmacodynamics of the clinical stage drug candidate apramycin in time kill and mouse lung infection models. "
09/01/2021 - "PKPD simulations suggested a previously predicted dose of 30 mg/kg in patients (creatinine clearance (CLCr) = 80 mL/min) to result in >99% probability of -2 log target attainment for MICs up to 16 μg/mL. This study provides proof of concept for the efficacy of EBL-1003 in the treatment of CRAB lung infections. "

08/26/2020 - "Apramycin is used exclusively for the treatment of Escherichia coli (E.coli) infections in swine around the world since the early 1980s. "
09/01/1986 - "During 1983, a series of trials was carried out in Greece, Italy and Jordan, to test the efficacy of the aminocyclitol antibiotic apramycin as a treatment for naturally acquired Escherichia coli infections in broilers. "
09/01/1986 - "An evaluation of apramycin soluble powder for the treatment of naturally acquired Escherichia coli infections in broilers."

05/01/1997 - "Single doses of apramycin at the rate of 75 mg kg-1 body weight were given to broiler chickens by intracrop, i.m. "
05/04/2014 - "Korea beechwood creosote was supplemented into three test groups with 0.03 g/kg, 0.07 g/kg and 0.1 g/kg body weight/day without antibiotic support, along with a positive control of Apramycin sulphate (at 0.5% of the daily feed) and a negative control. "
02/01/2008 - "The allometric equations relating the half-life, the volume of distribution and the total body clearance of gentamicin, amikacin, tobramycin, kanamycin and apramycin to body weight for mammalian and mammalian + avian species were defined. "

11/01/2014 - "We assessed the antibacterial efficacy of apramycin in two murine models of infection, Mycobacterium tuberculosis aerosol infection and Staphylococcus aureus septicemia. "
07/01/2023 - "In vitro activities of omadacycline, eravacycline, cefiderocol, apramycin, and comparator antibiotics against Acinetobacter baumannii causing bloodstream infections in Greece, 2020-2021: a multicenter study."

11/01/2014 - "We assessed the antibacterial efficacy of apramycin in two murine models of infection, Mycobacterium tuberculosis aerosol infection and Staphylococcus aureus septicemia. "