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UM-424
structure
Also Known As:
1-dimethylisopropylamino-3-(2-phenylphenoxy)propan-2-ol chloride; UM 424; 3-((1,1'-biphenyl)-2-yloxy)-2-hydroxy-N,N-dimethyl-N-(1-methylethyl)-1-propanaminium, chloride
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Propanolamines: 4
UM-424: 1
Alcohols: 595
Amino Alcohols: 20
Propanolamines: 4
UM-424: 1
Propanols: 3
Propanolamines: 4
UM-424: 1
Related Diseases
1.
Ventricular Fibrillation
04/01/1987 - "
These findings suggest UM-424 is ineffective in preventing the development of ischemic ventricular fibrillation in the presence of previous myocardial injury, despite the efficacy of this agent in suppressing other experimentally induced ventricular arrhythmias.
"
04/01/1987 - "
However, the incidence of subsequent ventricular fibrillation developing in response to acute ischemia at a site remote from previous myocardial infarction was 100% in both UM-424 (n = 8)- and vehicle (n = 8)-treated postinfarction dogs.
"
2.
Ventricular Tachycardia
04/01/1987 - "
In conscious dogs 4-7 days after anterior myocardial infarction, UM-424 administered intravenously in a single (5.0 mg/kg) or multiple (5.0 mg/kg q 6 h for 24 h) dose schedule increased the ventricular refractory period from 146 +/- 4 to 180 +/- 3 ms (p less than 0.01), and suppressed the initiation of ventricular tachycardia by programmed ventricular stimulation in six of nine postinfarction dogs tested.
"
3.
Myocardial Infarction
04/01/1987 - "
In conscious dogs 4-7 days after anterior myocardial infarction, UM-424 administered intravenously in a single (5.0 mg/kg) or multiple (5.0 mg/kg q 6 h for 24 h) dose schedule increased the ventricular refractory period from 146 +/- 4 to 180 +/- 3 ms (p less than 0.01), and suppressed the initiation of ventricular tachycardia by programmed ventricular stimulation in six of nine postinfarction dogs tested.
"
04/01/1987 - "
However, the incidence of subsequent ventricular fibrillation developing in response to acute ischemia at a site remote from previous myocardial infarction was 100% in both UM-424 (n = 8)- and vehicle (n = 8)-treated postinfarction dogs.
"
4.
Ischemia
04/01/1987 - "
However, the incidence of subsequent ventricular fibrillation developing in response to acute ischemia at a site remote from previous myocardial infarction was 100% in both UM-424 (n = 8)- and vehicle (n = 8)-treated postinfarction dogs.
"