|1.||Wang, Chonggang: 4 articles (01/2015 - 02/2011)|
|2.||Zuo, Zhenghong: 4 articles (01/2015 - 02/2011)|
|3.||Sekino, Yuko: 3 articles (08/2015 - 05/2013)|
|4.||Kotake, Yaichiro: 3 articles (08/2015 - 05/2013)|
|5.||Yamada, Shigeru: 3 articles (08/2015 - 05/2013)|
|6.||Kanda, Yasunari: 3 articles (08/2015 - 05/2013)|
|7.||Whalen, Margaret M: 3 articles (11/2010 - 01/2007)|
|8.||Wu, Tian: 2 articles (05/2014 - 02/2011)|
|9.||Kato, Takuma: 2 articles (11/2013 - 05/2004)|
|10.||Kuribayashi, Kagemasa: 2 articles (11/2013 - 05/2004)|
05/15/1989 - "In preliminary reports, 5 ppm tributyltin produced no detectable increase in tumor incidence, and 0.5 ppm produced no detectable immunotoxicity in long-term studies. "
04/01/2007 - "Tributyltin (TBT) has been shown to disrupt the ability of natural killer (NK) cells to destroy tumor targets in vitro even at exposures of 25 nM for 24 h, but cell viability was not significantly impacted. "
06/01/2006 - "We also found that the environmental contaminant tributyltin (TBT), at concentrations of 300-500 nM, decreased tumor-cell lysis by NK cells, as well as their intracellular levels of cAMP. "
11/01/2010 - "Previous studies have shown that exposure of NK cells to tributyltin (TBT) greatly diminishes their ability to destroy tumor cells (lytic function) while activating mitogen-activated protein kinases (MAPK) (p44/42, p38, and JNK) in NK cells. "
01/01/2007 - "The purpose of this study was to investigate the role that tributyltin (TBT)-induced decreases in ATP levels may play in TBT-induced decreases in the tumor lysing (lytic) function of natural killer (NK) cells. "
|2.||Prostatic Neoplasms (Prostate Cancer)
12/01/2000 - "Enhancement of androgen-dependent transcription and cell proliferation by tributyltin and triphenyltin in human prostate cancer cells."
04/12/2012 - "Tributyltin-TAAG and the fluorous analogue were synthesized in high yield using simple click chemistry and the products labeled in greater than 95% RCY with (123)I. A TAAG derivative of an inhibitor of prostate-specific membrane antigen was prepared and radiolabeled with (123)I in 85% yield where biodistribution studies in LNCap prostate cancer tumor models showed rapid clearance of the agent from nontarget tissues and tumor accumulation of 20% injected dose g(-1) at 1 h. "
|3.||Congenital Abnormalities (Deformity)
04/01/2010 - "Alligators living in contaminated lakes have shown a significant reduction in penis size and fish exposed to tributyltin have shown tail deformities and abnormal eye development. "
02/01/2013 - "The authors found that the occurrence of mouthpart deformities was significantly correlated with inbreeding, whereas no correlation was found with the tributyltin exposure. "
02/01/2013 - "The authors assessed rates of mouthpart deformities in tributyltin-exposed, inbred, and outcrossed Chironomus riparius larvae over multiple generations. "
06/01/2012 - "Tributyltin (TBT) is a ubiquitous marine environmental contaminant, which has been known to cause axial skeletal deformities in fish embryos. "
09/01/1988 - "Tributyltin is a teratogen in producing deformities in limbs of the fiddler crab, Uca pugilator."
07/04/2011 - "Our present study showed that treatment with C-Pc protects the rats from Tributyltin (TBT) induced thymic atrophy. "
04/01/1998 - "Numerous studies suggest that tributyltin (TBT) is a potent immunotoxicant in nontarget organisms with lymphoid atrophy being a hallmark response. "
05/01/2004 - "It has been shown that a relatively high dose of tributyltin (TBT), which is recognized as a particularly notable environmental pollutant, exerts immunotoxic effects such as thymic atrophy via induction of T cell apoptosis. "
01/01/1993 - "Thymocyte apoptosis as a mechanism for tributyltin-induced thymic atrophy in vivo."
04/15/1991 - "Atrophy of the thymus, the most prominent sign of toxicity of di- and tributyltin compounds in mammalian species, was not observed in early life stages of rainbow trout. "
12/30/2005 - "Tributyltin is able to cause hemolysis of human erythrocytes in a dose-dependent manner. "
09/01/1992 - "Red blood cells (RBC) exposed to micromolar concentrations of tributyltin compounds (TBTX) undergo morphological changes and hemolysis. "
03/01/1987 - "A log-linear statistical model demonstrated an association of hemolysis with both tri-n-butyltin aggregate formation and shape transformation. "
10/01/1986 - "Hydrophobic tributyltin (TBT) compounds at concentrations greater than 10 microM caused hemolysis of human erythrocytes and formed structures in plasma membranes. "
08/01/1986 - "Tributyltin has a sharp cut-off concentration for induction of hemolysis. "
|1.||human glutamate carboxypeptidase II
|6.||bis(tri-n-butyltin)oxide (tributyltin oxide)
|8.||Adenosine Triphosphate (ATP)
|9.||Mitogen-Activated Protein Kinases