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deoxycytidine deaminase

Networked: 16 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Greene, Warner C: 3 articles (02/2007 - 05/2005)
2. Soros, Vanessa B: 3 articles (02/2007 - 05/2005)
3. Bergman, A M: 2 articles (01/2009 - 02/2004)
4. Peters, G J: 2 articles (01/2009 - 02/2004)
5. Prochnow, Courtney: 1 article (08/2012)
6. Pham, Phuong: 1 article (08/2012)
7. Goodman, Myron F: 1 article (08/2012)
8. Chen, Xiaojiang S: 1 article (08/2012)
9. Mu, Yunxiang: 1 article (08/2012)
10. Tsuchida, Akihiko: 1 article (07/2012)

Related Diseases

1. Neoplasms (Cancer)
10/01/1987 - "Deoxycytidine deaminase is present in all the tissues which were analyzed, although its activity is lower in some of the tumor samples. "
04/01/2007 - "Its unnatural stereochemistry renders it insensitive to some mechanisms of resistance of tumor cells to D-nucleosides, such as deamination by deoxycytidine deaminase and decreased active uptake by nucleoside transporters. "
05/01/1987 - "A critical feature of this chemotherapeutic strategy using FdCyd plus H4Urd was that the elevated level of cytidine deaminase in LLC tumor tissue was inhibited less than 10% by the administration of 25 mg/kg H4Urd, whereas deoxycytidine deaminase activities in normal tissues (including bone marrow and intestine) were inhibited greater than 93%.(ABSTRACT TRUNCATED AT 400 WORDS)"
01/01/2009 - "The aim of this phase 0 study was to investigate whether gemcitabine passes the blood-tumor barrier, and is phosphorylated in the tumor by deoxycytidine kinase (dCK) to gemcitabine nucleotides in order to enable radiosensitization, and whether it is deaminated by deoxycytidine deaminase (dCDA) to dFdU. "
04/01/1982 - "The activities of cytidine triphosphate synthetase, deoxycytidine monophosphate deaminase, uridine kinase, thymidine kinase, thymidine monophosphate kinase and DNA polymerase were markedly increased in tumor tissues, compared with those in the corresponding normal tissues, while the activities of deoxycytidine kinase, cytidine deaminase and deoxycytidine deaminase were only slightly increased. "
2. Infection
3. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4. Leukemia
5. Hyper-IgM Immunodeficiency Syndrome (Hyper-IgM Syndrome)

Related Drugs and Biologics

1. Deoxycytidine Kinase
2. Nucleotides
3. gemcitabine
4. Thymidine Kinase
5. Cytidine Deaminase
6. Cytarabine (Cytosar-U)
7. Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
8. Uridine Kinase
9. Ribonucleotide Reductases (Ribonucleotide Reductase)
10. Nucleosides

Related Therapies and Procedures

1. Remission Induction
2. Drug Therapy (Chemotherapy)