|1.||Takahashi, Ryotaro: 3 articles (11/2005 - 01/2003)|
|2.||Ito, Masafumi: 3 articles (11/2005 - 01/2003)|
|3.||Okumura, Kenji: 3 articles (11/2005 - 01/2003)|
|4.||Matsui, Hideo: 3 articles (11/2005 - 01/2003)|
|5.||Murohara, Toyoaki: 2 articles (11/2005 - 06/2003)|
|6.||Asai, Toru: 2 articles (11/2005 - 06/2003)|
|7.||Saburi, Yoshihiro: 2 articles (06/2003 - 01/2003)|
|8.||Matsubara, Kenichiro: 2 articles (06/2003 - 01/2003)|
|9.||Kamiya, Hiroki: 2 articles (06/2003 - 01/2003)|
|10.||Hirano, Sachiko: 1 article (06/2007)|
10/01/1995 - "We have synthesized and characterized a positron-emitting carbon-11-labeled 1,2-diacylglycerol to study phosphoinositide turnover in tumor cells. "
12/01/1985 - "Within 10 min of addition of the tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) to C3H/10T1/2 mouse embryo fibroblasts, there is a two-fold increase in the level of cellular 1,2-diacylglycerol levels compared to controls. "
05/13/1982 - "We recently reported that treatment of differentiated chick embryo myoblasts in culture with the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) caused a 2-fold increase in the level of 1,2-diacylglycerol in the plasma membrane fraction within 15-30 min (Grove, R.I. and Schimmel, S.D. "
10/01/1995 - "On the basis of the concept of carbon-11-labeled 1,2-diacylglycerol as a specific probe for visualizing the tumor signal transduction in vivo, we obtained proliferating images of implanted C6 glioma cells in the rat brain by autoradiography and visualized the proliferation signal in human glioma by positron emission tomography."
03/19/1991 - "The results of these studies demonstrated that: (1) total protein kinase C activity was reduced by approximately 35% and 60%, respectively, in the 'uninvolved' colonic mucosa and tumors of carcinogen-treated rats compared to their control counterpart values; (2) in the 'uninvolved' mucosa, this decrease in total activity was secondary to a decrease solely in cytosolic protein kinase C, whereas, in tumors both membrane and cytosolic activities were reduced; and (3) 1,2-diacylglycerol mass was significantly increased in colonic tumors versus control values. "
05/01/1989 - "1-Oleoyl-2-acetyl-sn-glycerol (OAG), the membrane-permeable analogue of 1,2-diacylglycerol (DAG), which stimulates ascites tumor cell proliferation, was used to study its effect on phosphoinositide metabolism. "
08/01/1988 - "This study shows that the membrane-permeable stereospecific 1-oleoyl-2-acetyl-sn-glycerol (OAG), which is the analog of the natural 1,2-diacylglycerol (DAG), can stimulate the growth of ascites tumor cells. "
04/01/1991 - "We determined the level of 1,2-diacylglycerol and its fatty acid composition in heart tissues from Syrian hamsters with hereditary cardiomyopathy (BIO 14.6 strain) during the development of congestive heart failure from 90 days to 240 days of age. "
09/01/1988 - "The results of this study suggest that the development of cardiomyopathy induced by streptozocin injection is associated with a high 1,2-diacylglycerol level, which may result in the activation of protein kinase C. "
|4.||Cardiomegaly (Heart Hypertrophy)
01/01/2003 - "Changes in distinct species of 1,2-diacylglycerol in cardiac hypertrophy due to energy metabolic disorder."
06/01/2003 - "Impact of alpha-tocopherol on cardiac hypertrophy due to energy metabolism disorder: the involvement of 1,2-diacylglycerol."
07/01/1995 - "1,2-Diacylglycerol (DAG) is an intracellular signal mediator that may initiate protein synthesis and cardiac hypertrophy via activation of protein kinase C. "
06/01/1992 - "1,2-Diacylglycerol may initiate cardiac hypertrophy, probably by activating protein kinase C. "
05/13/1992 - "Enalapril may decrease cardiac hypertrophy in SHR by lowering myocardial 1,2-diacylglycerol production."
06/01/1992 - "During ischemia and reperfusion there is a significant increase in the content of 1,2-diacylglycerol (DAG), which is the physiological activator of PKC, but under the conditions occurring in the ischemic/postischemic livers DAG apparently cannot bind to the enzyme and fulfill its function. "
02/01/1991 - "Although the increase in free fatty acid contents continued, 1,2-diacylglycerol did not show further increase after 30-min ischemia. "
12/03/1990 - "The myocardial 1,2-diacylglycerol (DG) and phospholipid levels during ischemia and reperfusion were studied in open-chest dogs by means of sequential epicardial minibiopsies, followed by quantification based on mass measurement technique. "
08/01/1986 - "The amount of 1,2-diacylglycerol increased by 82.9% in gerbil forebrain during 5 min of ischemia induced by bilateral carotid ligation. "
|1.||Protein Kinase C
|4.||Interleukin-6 (Interleukin 6)
|5.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|6.||RNA (Ribonucleic Acid)
|8.||Epidermal Growth Factor (EGF)
|10.||Protein Kinase Inhibitors