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1,2-diacylglycerol

Networked: 40 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Takahashi, Ryotaro: 3 articles (11/2005 - 01/2003)
2. Ito, Masafumi: 3 articles (11/2005 - 01/2003)
3. Okumura, Kenji: 3 articles (11/2005 - 01/2003)
4. Matsui, Hideo: 3 articles (11/2005 - 01/2003)
5. Murohara, Toyoaki: 2 articles (11/2005 - 06/2003)
6. Asai, Toru: 2 articles (11/2005 - 06/2003)
7. Saburi, Yoshihiro: 2 articles (06/2003 - 01/2003)
8. Matsubara, Kenichiro: 2 articles (06/2003 - 01/2003)
9. Kamiya, Hiroki: 2 articles (06/2003 - 01/2003)
10. Hirano, Sachiko: 1 article (06/2007)

Related Diseases

1. Neoplasms (Cancer)
10/01/1995 - "We have synthesized and characterized a positron-emitting carbon-11-labeled 1,2-diacylglycerol to study phosphoinositide turnover in tumor cells. "
12/01/1985 - "Within 10 min of addition of the tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) to C3H/10T1/2 mouse embryo fibroblasts, there is a two-fold increase in the level of cellular 1,2-diacylglycerol levels compared to controls. "
05/13/1982 - "We recently reported that treatment of differentiated chick embryo myoblasts in culture with the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) caused a 2-fold increase in the level of 1,2-diacylglycerol in the plasma membrane fraction within 15-30 min (Grove, R.I. and Schimmel, S.D. "
10/01/1995 - "On the basis of the concept of carbon-11-labeled 1,2-diacylglycerol as a specific probe for visualizing the tumor signal transduction in vivo, we obtained proliferating images of implanted C6 glioma cells in the rat brain by autoradiography and visualized the proliferation signal in human glioma by positron emission tomography."
03/19/1991 - "The results of these studies demonstrated that: (1) total protein kinase C activity was reduced by approximately 35% and 60%, respectively, in the 'uninvolved' colonic mucosa and tumors of carcinogen-treated rats compared to their control counterpart values; (2) in the 'uninvolved' mucosa, this decrease in total activity was secondary to a decrease solely in cytosolic protein kinase C, whereas, in tumors both membrane and cytosolic activities were reduced; and (3) 1,2-diacylglycerol mass was significantly increased in colonic tumors versus control values. "
2. Ascites
3. Cardiomyopathies (Cardiomyopathy)
4. Cardiomegaly (Heart Hypertrophy)
5. Ischemia

Related Drugs and Biologics

1. Protein Kinase C
2. 1-oleoyl-2-acetylglycerol
3. Streptozocin (Streptozotocin)
4. Interleukin-6 (Interleukin 6)
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. RNA (Ribonucleic Acid)
7. Phosphatidylcholines (Phosphatidylcholine)
8. Epidermal Growth Factor (EGF)
9. Calcium
10. Protein Kinase Inhibitors

Related Therapies and Procedures

1. Ligation