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cephalochromin

Also Known As:

SCH 45752; SCH-45752; 2,2',3,3'-tetrahydro-5,5',6,6',8,8'-hexahydroxy-2, 2'-dimethyl-9,9'-bi-4H-naphtho(2,3-b)pyran-4,4'-dione

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Lactams: 2198
    - beta-Lactams: 2386
      - Cephalosporins: 4007
        cephalochromin: 1
- Sulfur Compounds: 278
  - Thiazines: 3
    - Cephalosporins: 4007
      - cephalochromin: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - beta-Lactams: 2386
      - Cephalosporins: 4007
        cephalochromin: 1

Experts

1.	Chen, Wei-Lin: 1 article (04/2014)
2.	Chiang, Chun-Ping: 1 article (04/2014)
3.	Chung, Chi-Li: 1 article (04/2014)
4.	Guh, Jih-Hwa: 1 article (04/2014)
5.	Hsiao, Che-Jen: 1 article (04/2014)
6.	Hsiao, George: 1 article (04/2014)
7.	Lee, Tzong-Huei: 1 article (04/2014)
8.	Liu, Li-Ya: 1 article (04/2014)
9.	Wang, Shih-Wei: 1 article (04/2014)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 04/25/2014 - "The fungus-derived compound cephalochromin, isolated from the fermented broth of Cosmospora vilior YMJ89051501, shows growth-inhibitory and apoptotic activity against human lung cancer A549 cells in a concentration-dependent manner with an IC50 value of 2.8 μM at 48 h. " 04/25/2014 - "Taken together, this is the first report that cephalochromin induced an antiproliferative effect on human lung cancer cells through mitochondrial disruption and down-regulation of survivin, leading to cell cycle arrest at the G0/G1 phase, loss of MMP, and subsequently apoptotic cell death. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/25/2014 - "Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption."

Related Drugs and Biologics

1.	Matrix Metalloproteinases (MMPs)
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