nisoxetine

potent inhibitor for norepinephrine uptake into rat brain synaptosomes & brain; NM refers to (+-)-isomer; RN given refers to parent cpd; structure

Also Known As:

3-(2-methoxyphenoxy)-N-methyl-3-phenylpropylamine; 3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine; DL-N-methyl-3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine; LY 135252; LY 94939; LY-135252; Lilly 135252; Lilly 94939; N-methyl-gamma-(2-methylphenoxy)phenylpropanolamine; nisoxetine hydrochloride; nisoxetine hydrochloride, (+-)-isomer; nisoxetine, (+-)-isomer

Networked: 26 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Propylamines: 1
    - Fluoxetine: 3754
      - nisoxetine: 26

Experts

1.	Hall, F Scott: 2 articles (10/2012 - 10/2007)
2.	Sora, Ichiro: 2 articles (10/2012 - 10/2007)
3.	Uhl, George R: 2 articles (10/2012 - 10/2007)
4.	Bishop, Christopher: 1 article (11/2016)
5.	Conti, Melissa M: 1 article (11/2016)
6.	Hallmark, Joy: 1 article (11/2016)
7.	Lindenbach, David: 1 article (11/2016)
8.	Meadows, Samantha M: 1 article (11/2016)
9.	Melikhov-Sosin, Mitchell: 1 article (11/2016)
10.	Werner, David F: 1 article (11/2016)

Related Diseases

1.	Neuroblastoma 01/01/2013 - "In in vitro studies, the voltage-clamp method was employed to examine whether nisoxetine blocked Na(+) currents in mouse neuroblastoma N2A cells. " 06/15/2001 - "In this study we have examined the effects of a range of local anaesthetic agents on the uptake of [3H]norepinephrine ([3H]NE) (as a surrogate for guanethidine) and the binding of [3H]nisoxetine to the NE transporter in cultured SH-SY5Y human neuroblastoma cells. "
2.	Body Weight (Weight, Body) 04/01/2007 - "Consequently, the acute effects of DA and NE reuptake inhibition on energy homeostasis were determined by measuring food intake and body weight in mice following peripheral (intraperitoneal (i.p.)) administration of either BUP, a selective DA (GBR12783), or a selective NE (nisoxetine (NIS)) reuptake inhibitor. " 01/01/2013 - "The present studies determined how high-fat feeding and body weight gain alter the sensitivity to the feeding suppression and neural activation to a selective norepinephrine reuptake inhibitor, nisoxetine. "
3.	Obesity 08/01/1997 - "5. The results of this study demonstrate that inhibition of 5-HT and noradrenaline reuptake by sibutramine, venlafaxine, duloxetine, or by a combination of fluoxetine and nisoxetine, markedly reduces food intake in freely-feeding rats and suggest that this may be a novel approach for the treatment of obesity."
4.	Alzheimer Disease (Alzheimer's Disease) 12/17/1993 - "The present study determined whether [3H]nisoxetine binding to norepinephrine transporter sites would be altered uniformly throughout the locus coeruleus in Alzheimer's disease. " 12/17/1993 - "The loss of [3H]nisoxetine binding to norepinephrine transporter sites may be attributed to a loss of norepinephrine transporter sites located on terminals of noradrenergic neurons in the locus coeruleus in Alzheimer's disease."
5.	Ischemia 11/01/1995 - "Nisoxetine, a structurally unrelated inhibitor of uptake1, also suppressed ischemia-evoked ventricular fibrillation. " 11/01/1988 - "The effects of the antidepressant or putative antidepressant drugs desipramine, 2-hydroxy desipramine, nisoxetine, (S)-oxaprotiline and (R)-oxaprotiline with respect to this release mechanism were investigated in the isolated rat heart submitted to total stop-flow ischemia and subsequent reperfusion. "

Related Drugs and Biologics

1.	Norepinephrine (Noradrenaline)
2.	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)
3.	Serotonin (5 Hydroxytryptamine)
4.	Fluoxetine (Prozac)
5.	Guanethidine
6.	Venlafaxine Hydrochloride (Effexor)
7.	Duloxetine Hydrochloride (Cymbalta)
8.	sibutramine (Meridia)
9.	Desipramine (Pertofrane)
10.	Adrenergic Receptors (Adrenergic Receptor)