|1.||Pap, B: 1 article (06/2009)|
|2.||Mózes, M M: 1 article (06/2009)|
|3.||Zádori, Z S: 1 article (06/2009)|
|4.||Mátyus, P: 1 article (06/2009)|
|5.||Al-Khrasani, M: 1 article (06/2009)|
|6.||Gyires, K: 1 article (06/2009)|
|7.||Shujaa, N: 1 article (06/2009)|
|8.||Pancaro, Carlo: 1 article (09/2002)|
|9.||Duflo, Frédéric: 1 article (09/2002)|
|10.||Eisenach, James C: 1 article (09/2002)|
|1.||Hypotension (Low Blood Pressure)
12/01/1978 - "It is suggested that St 91 can cross the blood-brain barrier although why no hypotension is observed after i.v. administration still remains obscure."
06/01/1986 - "Intravenous administration of clonidine, but not of St 91, decreased the activity of the locus coeruleus and produced a prolonged hypotension, thus suggesting a central mechanism for these effects. "
06/01/1986 - "However, only clonidine decreased the mean blood pressure after intracerebroventricular administration suggesting that either the receptors mediating decreases in the activity of the locus coeruleus are different to those mediating hypotension, or that St 91 does not distribute to sites involved in the control of blood pressure even after intracerebroventricular administration. "
12/17/1982 - "Prazosin (5 micrograms/kg i.v.) reduced both the mean resting blood pressure and the maximum pressor response to St 91 (8 and 16 micrograms/kg i.v.) and unmasked a small secondary hypotension. "
12/01/1978 - "It was found that, after pretreatment with phenoxybenzamine (1.5 mg/kg, i.v.) an infusion of St 91 (8 microgram/kg/min, 2 min) produced a much diminished pressor response and a later small hypotension, while still causing the same degree of bradycardia. "
12/17/1982 - "Intravenous administration of St 91 (2-(2,6-diethylphenylimino)-imidazolidine hydrochloride) (8 and 16 micrograms/kg) to anaesthetized cats, produced a dose-related but brief rise in blood pressure accompanied by bradycardia. "
05/01/1975 - "4. St 91 did not lower blood pressure and did not facilitate vagal reflex bradycardia after i.v. injection in dogs, but was active after intracisternal injection. "
12/17/1982 - "The results show that the long-lasting residual bradycardia caused by i.v. St 91 is due to activation of central alpha-adrenoceptors. "
12/17/1982 - "vert.), given after St 91 (16 micrograms/kg i.v.) abolished the residual bradycardia whereas pretreatment with piperoxan (150 micrograms/kg, intracisternally) inhibited both the initial and the residual bradycardia. "
12/17/1982 - "Atropine (1 mg/kg i.v.) did not alter the pressor response to St 91 (16 micrograms/kg i.v.) but depressed the initial bradycardia accompanying the pressure rise. "
12/19/1983 - "Clonidine (5-20 micrograms) did not significantly alter nociceptive thresholds, while St-91 (20 micrograms) produced a brief hyperalgesia in the tail-flick test. "
06/01/2009 - "Clonidine (0.094 micromol/kg p.o.) and rilmenidine (0.014 micromol/kg p.o.) in gastroprotective dose range, as well as ST-91 (2.2 micromol/kg p.o.), a clonidine analogue showing higher affinity to alpha(2B)-adrenoceptor subtype than to alpha(2A)-one, inhibited the carrageenan-induced hyperalgesia in Randall-Selitto test, the antinociceptive action was reversed by yohimbine (5 micromol/kg s.c.) and the alpha(2B)-adrenoceptor antagonist prazosin (0.24 micromol/kg i.p.). "
05/01/1999 - "To test the hypothesis that pulmonary alterations are more important than hemodynamic changes in alpha2-agonist-induced hypoxemia in ruminants, the cardiopulmonary effects of incremental doses of (4-[1-(2,3-dimethylphenyl)ethyl]-1H-imadazole) hydrochloride (medetomidine; 0.5, 1.0, 2.0, and 4 micrograms/kg) and 2-(2, 6-diethylphenylamino)-2-imidazol (ST-91; 1.5, 3.0, 6.0, and 12 micrograms/kg) were compared in five halothane-anesthetized, ventilated sheep using a placebo-controlled randomized crossover design. "
01/01/1988 - "Although both clonidine (3-15 micrograms/kg) and ST-91 (3-30 micrograms/kg) produced arterial hypoxemia, clonidine was more effective (arterial PO2 was 91 +/- 4 mm Hg after saline, 30 +/- 3 mm Hg after 15 micrograms/kg of clonidine and 43 +/- 6 mm Hg after 30 micrograms/kg of ST-91; mean +/- S.E., P less than .0001). "
|1.||Clonidine (ST 155)
|6.||alpha-2 Adrenergic Receptors
|8.||Sulfobromophthalein (Sulfobromophthalein Sodium)
|9.||Adrenergic Receptors (Adrenergic Receptor)