|1.||Chow, Sharon: 2 articles (07/2014 - 06/2010)|
|2.||Fletcher, Mary T: 2 articles (07/2014 - 06/2010)|
|3.||Ossedryver, Selina M: 1 article (07/2014)|
|4.||McKenzie, Ross A: 1 article (06/2010)|
06/23/2010 - "However, literature relating to previous studies is complicated by taxonomic revisions, and the presence of simplexin has not previously been verified in all currently recognized taxa capable of inducing pimelea poisoning syndrome, with no previous chemical studies of P. "
06/23/2010 - "penicillaris contained simplexin at up to 55 mg/kg dry weight and would be expected to cause poisoning if animals consumed sufficient plant material."
06/23/2010 - "microcephala also demonstrated the presence of simplexin in these species but at far lower concentrations, consistent with the limited reports of stock poisoning associated with these species. "
06/23/2010 - "Pimelea poisoning (also known as St. George disease and Marree disease) has been attributed to the presence of the diterpenoid orthoester simplexin in these species. "
07/30/2014 - "In this study, mild Pimelea poisoning was induced at a daily dose of 12.5 mg Pimelea/kg body weight per day, equivalent to 2.5 μg simplexin/kg body weight per day, demonstrating the high potential toxicity of these plant species. "
|2.||Body Weight (Weight, Body)
07/01/1988 - "In the standardized initiation/promotion protocol on the back skin of mice, some of the irritant DTE exhibit tumor-promoting activities higher than that of simplexin."
12/01/1994 - "O1 is an appropriate starting material for the preparation of the daphnane prototype irritant and tumor-promoting orthoester simplexin (SIM) especially of a multiple tritium-labeled form thereof. "
07/30/2014 - "Pimelea species (or desert riceflower) are small native plants endemic to the drier inland pastoral regions of Australia, which cause a unique syndrome in grazing cattle characterized by submandibular edema and edema in the brisket area as a result of right-sided heart failure attributed to the toxin simplexin, 1. Field evidence suggests that poisoning can occur through minor, inadvertent consumption of Pimelea plant material, but the minimum simplexin intake required to induce Pimelea poisoning is not known. "