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3-hydroxynorvaline

RN given refers to cpd without isomeric designation; structure

Also Known As:

3-hydroxynorvaline, threo-(DL)-isomer; alpha-amino beta-hydroxyvaleric acid; beta-hydroxynorvaline

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Threonine: 2168
      - 3-hydroxynorvaline: 3
  - Neutral Amino Acids: 200
    - Threonine: 2168
      - 3-hydroxynorvaline: 3

Related Diseases

1.	Neoplasms (Cancer) 09/10/1980 - "The importance of threonine in the Asn-X-Thr recognition sequence for asparagine-linked glycosylation was tested by examining the effect of a threonine analog, beta-hydroxynorvaline, on co-translational glycosylation in Krebs' II ascites tumor lysates. "
2.	Lymphoma (Lymphomas) 05/15/1985 - "The requirement for intact carbohydrates of glycoproteins at the cell surface was investigated after treatment of lymphoma cells with compounds which interfere at different steps in N-linked glycosylation: swainsonine and 1-deoxynojirimycin act at different levels during the processing, so that complex oligosaccharides cannot be formed; 2-deoxyglucose, beta-hydroxynorvaline, and tunicamycin completely prevent the formation of N-linked (high-mannose as well as complex) oligosaccharides. "
3.	Infections 10/19/1987 - "Treatment of HSV-infected cells with 5-10 mM beta-hydroxynorvaline (Hnv), a threonine analog, specifically affects herpesvirus DNA replication: both the rate of and total DNA synthesis are reduced, the former approximately 15-fold by Hnv (6 h post-infection) and the latter by 12-fold (between 3 and 12 h post-infection). "
4.	Ascites 09/10/1980 - "The importance of threonine in the Asn-X-Thr recognition sequence for asparagine-linked glycosylation was tested by examining the effect of a threonine analog, beta-hydroxynorvaline, on co-translational glycosylation in Krebs' II ascites tumor lysates. "

Related Drugs and Biologics

1.	Threonine (L-Threonine)
2.	1-Deoxynojirimycin (1 Deoxynojirimycin)
3.	Swainsonine
4.	Tunicamycin
5.	Oligosaccharides
6.	Mannose (D-Mannose)
7.	Glycoproteins (Glycoprotein)
8.	DNA (Deoxyribonucleic Acid)
9.	Deoxyglucose (2 Deoxy D glucose)
10.	Carbohydrates

Related Therapies and Procedures

1.	Aftercare (After-Treatment)