|1.||Bueno, L: 2 articles (03/2010 - 10/2001)|
|2.||Lee, Kwang Jae: 1 article (10/2015)|
|3.||Róka, Richárd: 1 article (05/2014)|
|4.||Annaházi, Anita: 1 article (05/2014)|
|5.||Wittmann, Tibor: 1 article (05/2014)|
|6.||Rosztóczy, András: 1 article (05/2014)|
|7.||O'Mahony, V: 1 article (02/2014)|
|8.||Personnic, S: 1 article (02/2014)|
|9.||Dapoigny, M: 1 article (02/2014)|
|10.||Grimaud, J C: 1 article (02/2014)|
|1.||Abdominal Pain (Pain, Abdominal)
03/01/2010 - "Alverine citrate/simeticone combination was significantly more effective than placebo in relieving abdominal pain/discomfort in patients with IBS."
06/01/2002 - "The severity and frequency of abdominal pain improved in 66% and 68% of patients treated with alverine citrate vs. 58% and 69% of the placebo group, but these differences were not significant. "
03/01/2010 - "To evaluate the efficacy of alverine citrate and simeticone combination in patients with IBS-related abdominal pain/discomfort. "
03/01/2010 - "At week 4, alverine citrate and simeticone group had lower VAS scores of abdominal pain/discomfort (median: 40 mm vs. 50 mm, P = 0.047) and higher responder rate (46.8% vs. 34.3%, OR = 1.3; P = 0.01) as compared with placebo group. "
06/01/2002 - "The mean percentage reduction in the scores for abdominal pain from baseline to the final assessment, although greater in the alverine citrate group (43.7%) compared with the placebo group (33.3%), was not statistically significant. "
|2.||Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
02/01/2014 - "On-demand treatment with alverine citrate/simeticone compared with standard treatments for irritable bowel syndrome: results of a randomised pragmatic study."
06/01/2002 - "Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial."
04/01/2010 - "Alverine citrate, simeticone, and Rome III irritable bowel syndrome."
03/01/2010 - "Alverine citrate and simeticone combination has been used for almost 20 years in irritable bowel syndrome (IBS), but supportive scientific evidence of efficacy was limited. "
12/01/2002 - "Alverine is an antispasmodic drug which is especially used in patients with irritable bowel syndrome. "
08/01/2004 - "Although alverine citrate hepatotoxicity was related to an immune mechanism in the first case, several features such as absence of predictable dose-dependent toxicity of alverine citrate in a previous study and absence of hypersensitivity manifestations in our patient are suggestive of a metabolic type of idiosyncratic toxicity."
04/01/2013 - "Administered alone at 10 mg/kg p.o., alverine also reduced stress-induced hypersensitivity to distension; lower doses were inactive. "
04/01/2013 - "However, alverine administered at an inactive dose with simethicone suppressed stress-induced hypersensitivity to distension. "
04/01/2013 - "The antinociceptive effects of alverine and simethicone, separately or in association, were evaluated on stress-induced colonic hypersensitivity to distension in rats. "
10/01/2001 - "These results suggest that 5-HTP-induced rectal hypersensitivity involves 5-TH1A receptors and that alverine citrate acts as a selective antagonist at the 5-HT1A receptor subtype to block both 5-HTP and 8-OH-DPAT-induced rectal hypersensitivity."
09/01/2008 - "A prospective, randomized, controlled trial in a consecutive series of patients was conducted to compare alverine citrate as an antispasmodic agent for relaxation of spasm with elective colonoscopy. "
09/01/2008 - "The aim of this study was to determine the effects of alverine citrate plus simethicone on the cecal intubation time, colonic spasm and bowel cleanliness. "
02/01/2011 - "Four studies conducted in women with pregnancies <8 completed weeks' gestation found that prophylactic acetaminophen, acetaminophen+codeine, ibuprofen or alverine did not reduce medical abortion pain; however, administration of ibuprofen after onset of cramping reduced pain and subsequent analgesia use. "
|3.||Serotonin 5-HT1 Receptor Antagonists
|4.||Serotonin 5-HT1 Receptor Agonists
|6.||5-Hydroxytryptophan (5 Hydroxytryptophan)
|10.||Proteasome Endopeptidase Complex (Proteasome)