motretinide

exerts a therapeutic influence on chemically induced papillomas & carcinomas of the skin in mice; RN given refers to cpd without isomeric designation; structure

Also Known As:

Ro 11-1430; Ro 11-1430, (all-E)-isomer; TMMP ethyl ester; TMMP-ERA; Tasmaderm; trimethylmethoxyphenyl-N-ethyl retinamide; trans-N-ethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenamide

Networked: 10 relevant articles (1 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Acne Vulgaris 01/01/1984 - "Motretinide is considered an alternative in the treatment of papulopustular acne in young adults." 01/01/1987 - "Motretinide is the ethylamide of tretinoin and is reported to be effective in the local treatment of acne. " 01/01/1984 - "30 patients with acne vulgaris were treated topically with motretinide 0.1% vanishing cream or benzoyl peroxide 5% gel in an open study. " 01/01/1981 - "The clinical efficacy and tolerance of a new retinoic acid derivative, Ro 11-1430, in the treatment of acne vulgaris have been compared with those of tretinoin in a double-blind trial with 60 patients during 8 weeks. " 01/01/1984 - "Motretinide versus benzoyl peroxide in the treatment of acne vulgaris."
2.	Erythema 01/01/1979 - "Ro 11---1430 and placebo did not differ significantly regarding frequency and severity of erythema, desquamation and burning. " 01/01/1976 - "The side-effects erythema, desquamation and burning were significantly less frequent with Ro 11-1430 than with retinoic acid. " 01/01/1977 - "erythema, desquamation, burning and pruritus occurred more frequently and were more severe on vitamin A acid than on Ro 11-1430 and placebo which did not differ. "
3.	Pruritus (Itching) 01/01/1977 - "erythema, desquamation, burning and pruritus occurred more frequently and were more severe on vitamin A acid than on Ro 11-1430 and placebo which did not differ. "
4.	Papilloma (Papillomatosis) 01/01/1975 - "The compound: all-trans-N-ethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenamide = Ro 11-1430, exerts a therapeutic influence on chemically induced papillomas and carcinomas of the skin of mice. "
5.	Ichthyosis (Xeroderma) 10/01/1986 - "We investigated both tretinoin and motretinide in normal subjects and in patients with ichthyosis. "

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	Benzoyl Peroxide
3.	motretinide
4.	Retinoids
5.	Proteoglycans (Proteoglycan)