pretazettine

potent inhibitor of viral reverse transcriptase; narcissus alkaloid; prolongs life of leukemic mice; RN given refers to (6a beta,8 beta)-isomer; structure

Also Known As:

3,4,4a,5,6,6a-hexahydro-3-methoxy-5-methyl-8H- (1,3)dioxolo(6,7)(2)benzopyrano(3,4-c)indol-8-ol (stereoisomer); pretazettine hydrochloride, (6abeta,8beta)-isomer

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cimmino, Alessio: 1 article (04/2015)
2.	De Carvalho, Annelise: 1 article (04/2015)
3.	Evidente, Antonio: 1 article (04/2015)
4.	Frolova, Liliya V: 1 article (04/2015)
5.	Kiss, Robert: 1 article (04/2015)
6.	Kornienko, Alexander: 1 article (04/2015)
7.	Masi, Marco: 1 article (04/2015)
8.	Mathieu, Véronique: 1 article (04/2015)
9.	Pertsemlidis, Alexander: 1 article (04/2015)
10.	Rogelj, Snezna: 1 article (04/2015)

Related Diseases

1.	Leukemia 01/01/1988 - "Effect of pretazettine and viva-natural, a dietary seaweed extract, on spontaneous AKR leukemia in comparison with standard drugs." 01/01/1980 - "Therapeutic activity of pretazettine on Rauscher leukemia: comparison with the related Amaryllidaceae alkaloids." 01/01/1979 - "A narcissus alkaloid, pretazettine hydrochloride (PTZ) has been shown to be active against spontaneous AKR leukemia. " 01/01/1979 - "Therapeutic activity of pretazettine, a narcissus alkaloid, on spontaneous AKR leukemia." 01/01/1988 - "Antileukemic activity of pretazettine hydrochloride (PTZ: a narcissus alkaloid) and Viva-Natural (a seaweed extract) has been confirmed against spontaneous AKR T cell leukemia in mice containing 20% of advanced leukemia. "
2.	Lewis Lung Carcinoma 01/01/1986 - "Therapeutic potentials of pretazettine, standard anticancer drugs, and combinations on subcutaneously implanted Lewis lung carcinoma." 01/01/1983 - "Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. " 01/01/1983 - "Therapeutic activity of pretazettine, standard drugs, and the combinations on intraperitoneally implanted Lewis lung carcinoma in mice." 01/01/1981 - "Therapeutic activity of pretazettine on Lewis lung carcinoma." 01/01/1986 - "We reported previously that pretazettine hydrochloride (PTZ), a narcissus alkaloid, was found to be active against intraperitoneally implanted Lewis lung carcinoma. "
3.	T-Cell Leukemia (Leukemia, T Cell) 01/01/1988 - "Antileukemic activity of pretazettine hydrochloride (PTZ: a narcissus alkaloid) and Viva-Natural (a seaweed extract) has been confirmed against spontaneous AKR T cell leukemia in mice containing 20% of advanced leukemia. "
4.	Neoplasms (Cancer) 04/01/2015 - "Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer."
5.	Lymphoma (Lymphomas) 01/01/2009 - "Trisphaeridine and pretazettine increased the intracellular Rh-123 concentration 30- and 50-fold, respectively, as compared to the non-treated cells, and 2-O-acetyllycorine and trisphaeridine were demonstrated by means of the checkerboard method to enhance the antiproliferative activity of doxorubicin on L5178 MDR mouse lymphoma cells. "

Related Drugs and Biologics

1.	Alkaloids
2.	Amaryllidaceae Alkaloids
3.	Streptonigrin (Nigrin)
4.	Proteins (Proteins, Gene)
5.	Doxorubicin (Adriamycin)
6.	Antiviral Agents (Antivirals)
7.	Anti-Bacterial Agents (Antibiotics)
8.	trispheridine
9.	tazettine
10.	jonquailine