nylestriol (nilestriol)

Also Known As:

nilestriol; 17 alpha-ethinylestriol 3-cyclopentyl ether; 17 alpha-ethynylestriol 3-cyclopentyl ether; EE3CPE; LY 49825; LY-49825; Lilly 49825; 19-Norpregna-1,3,5(10)-trien-20-yne-16,17-diol, 3-(cyclopentyloxy)-, (16alpha,17alpha)-

Networked: 26 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Norsteroids: 16
      - Norpregnanes: 2
        Norpregnatrienes
        Ethinyl Estradiol: 861
        Quinestrol: 23
        nylestriol: 26
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Estradiol Congeners: 358
        Alkylated Estrogenic Steroids
        Ethinyl Estradiol: 861
        Quinestrol: 23
        nylestriol: 26

Experts

1.	Liao, Er-yuan: 3 articles (12/2004 - 02/2003)
2.	Zhou, Hou-de: 2 articles (12/2004 - 02/2003)
3.	Liao, Hui-juan: 2 articles (05/2003 - 02/2003)
4.	Luo, Xiang-hang: 2 articles (05/2003 - 02/2003)
5.	Wu, Xian-ping: 2 articles (05/2003 - 02/2003)
6.	Chen, O-J: 1 article (07/2013)
7.	Cheng, L-N: 1 article (07/2013)
8.	Hou, S-P: 1 article (07/2013)
9.	Huang, L-H: 1 article (07/2013)
10.	Teng, Y-C: 1 article (07/2013)

Related Diseases

1.	Osteoporosis 10/28/2001 - "The treatment of nilestriol and levenorgestrel may decrease the bone turnover and correct the imbalance to cure the osteoporosis." 03/01/1993 - "[Nilestriol prevents osteoporosis in ovariectomized rats]." 09/01/1998 - "These suggest the relative safety of Nilestriol replacement therapy for preventing menopausal osteoporosis." 01/01/1996 - "Our results indicate that osthole and nilestriol treatment provides protection against osteoporosis in OVX rats. " 06/01/2004 - "Animals were administered by GNK and nilestriol respectively, through gastric perfusion, for 3 months to observe the therapeutic effect of drug treatment on osteoporosis and the regulatory effect on endocrine and immune function. "
2.	Postmenopausal Osteoporosis 09/01/1997 - "To assess the effect of Nylestriol on postmenopausal osteoporosis in an attempt to reveal its mechanism. " 03/01/1993 - "It is convinced of using Nilestriol to prevent postmenopausal osteoporosis." 05/01/2003 - "In addition to the animal experiments, we evaluate the effect of Compound Nylestriol Tablet (CNT) on bone mineral density (BMD) in women with postmenopausal osteoporosis. " 05/01/2003 - "The effect of low dose nylestriol-levonorgestrel replacement therapy on bone mineral density in women with postmenopausal osteoporosis." 05/01/2003 - "Compound Nylestriol Tablet, which contains 0.5 mg of nylestriol (cyclopentylethinyl estriol) and 0.15 mg of levonorgestrel per tablet, was authorized as a new anti-osteoporotic agent for clinical trial in postmenopausal osteoporosis. "
3.	Body Weight (Weight, Body) 04/01/2009 - "The rats in the group C were treated daily with acupuncture at "Huantiao"(GB 30), "Housanli" (ST 36), "Yanglingquan"(GB 34) and "Weizhong"(BL 40) on the left hind legs; the rats in the group D were given orally Nilestriol solution (0.2 mg/mL) in a dose of 0.6 mL/100 g body weight, weekly. " 04/01/2009 - "The OVX rats were then subdivided into five groups treated with water, nylestriol (1 mg/kg body weight, weekly, orally) or icariin (ICA) (5, 25, and 125 mg/kg body weight, daily, orally) for 12 weeks. " 08/01/2004 - "Three dosage levels of CNT (0.039, 0.117 and 0.39 mg/kg body weight, daily), nylestriol (NYL, 0.30, 0.09 and 0.03 mg/kg body weight, daily) and levonorgestrel (LEV, 0.09, 0.027 and 0.009 mg/kg body weight, daily) were designed to prevent the bone loss of the osteoporotic rat model induced by RA and OVX respectively. "
4.	Osteosarcoma (Osteogenic Sarcoma) 12/01/2004 - "[Effect of nylestriol and levonorgestrel on the expression of Opg/OPGL in human osteosarcoma MG-63 cell lines]." 12/01/2010 - "[Effect of nylestriol and levonorgestrel on the expression of estrogen receptor subtypes in human osteosarcoma MG-63 cell lines]."
5.	Coronary Disease (Coronary Heart Disease) 04/28/2001 - "Forty perimenopausal women without coronary heart disease (CHD) and 30 postmenopausal women with CHD were studied, and 30 postmenopausal women were divided into two groups and treated randomly with either 2 mg nylestriol or placebo. " 01/01/1998 - "To investigate the relationship between sex hormone levels and blood lipids/immunity and to evaluate the therapeutical effects of nylestriol, 96 women without coronary heart disease(CHD) were studied during their perimenopausal period. "

Related Drugs and Biologics

1.	Lipids
2.	Lipoproteins (Lipoprotein)
3.	osthol (osthole)
4.	Estrogens (Estrogen)
5.	Estradiol (Delestrogen)
6.	Levonorgestrel (Plan B)
7.	Therapeutic Uses
8.	Misoprostol (Cytotec)
9.	Interleukin-6 (Interleukin 6)
10.	Tretinoin (Retinoic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Ovariectomy (Oophorectomy)
3.	Subcutaneous Injections