elastatinal

elastase inhibitor found in culture filtrates of various species of actinomyces

Also Known As:

Glutamamide, N-(((1-carboxy-3-methylbutyl)amino)carbonyl)glycyl-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N1-(1-methyl-2-oxoethyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - elastatinal: 5

Experts

1.	Ji, Z: 1 article (06/2000)
2.	Lu, X: 1 article (06/2000)
3.	Pei, Y: 1 article (06/2000)
4.	Xia, Y: 1 article (06/2000)
5.	Yang, X: 1 article (06/2000)

Related Diseases

1.	Xeroderma Pigmentosum (Kaposi's Disease) 10/01/1980 - "Effects of elastatinal, a protease inhibitor, on DNA repair and its cytotoxicity were investigated in normal human, xeroderma pigmentosum and Chinese hamster V79 cells. "
2.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 06/01/2000 - "The inhibitors to trypsin, leupeptin antipain and STI also repressed the activity of MAP-21, while chymostatin, TPCK and elastatinal TEI were shown no inhibition to its activity, demonstrating that, MAP-21 was a trypsin-like protease. "
3.	Breast Neoplasms (Breast Cancer) 07/01/1988 - "The inhibitory profiles of several proteinase-like peptidases active on synthetic peptide (MCA) substrates, present in sera and 100,000g supernatants of malignant tissue from patients with breast cancer, have been studied using a series of known inhibitors including epoxysuccinyl peptides (E-64, Ep-475), Z-Phe-Phe-diazomethane, PMSF, iodoacetamide, 1-10-O-phenanthroline, leupeptin, aprotinin, elastatinal and alpha 2-macroglobulin. "
4.	Bone Resorption 06/01/1993 - "Some protease inhibitors, e.g., E-64, pepstatin A, phosphoramidon, amastatin, bestatin, foroxymithine, did not influence the bone resorption, but some serine protease inhibitors such as PMSF, TLCK, TPCK and elastatinal inhibited the bone resorption at 10(-5) M, 10(-4) M, 10(-4) M, 10(-4) M, respectively. "
5.	Body Weight (Weight, Body) 07/01/1980 - "Elastatinal (100 mg/kg body weight twice a day) and chymostatin (100 mg/kg body weight once a day) did not inhibit formation of metastatic foci of AH7974 cells. "

Related Drugs and Biologics

1.	Tosylphenylalanyl Chloromethyl Ketone (TPCK)
2.	Protease Inhibitors (Protease Inhibitor)
3.	Peptide Hydrolases (Proteases)
4.	leupeptin
5.	chymostatin
6.	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)
7.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
8.	Trypsin
9.	Tosyllysine Chloromethyl Ketone
10.	Peptides (Polypeptides)