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di-n-octyl phthalate

plasticizer

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phthalic Acids: 1
      - di-n-octyl phthalate: 7

Experts

1.	Cao, Xueying: 1 article (09/2022)
2.	Lu, Yingang: 1 article (09/2022)
3.	Ma, Jun: 1 article (09/2022)
4.	Ren, Wenjie: 1 article (09/2022)
5.	Tan, Changyin: 1 article (09/2022)
6.	Teng, Ying: 1 article (09/2022)
7.	Ge, Ren-Shan: 1 article (01/2021)
8.	Hu, Miner: 1 article (01/2021)
9.	Huang, Tongliang: 1 article (01/2021)
10.	Ji, Haosen: 1 article (01/2021)

Related Diseases

1.	Body Weight (Weight, Body) 01/15/2021 - "In this study, male Sprague Dawley rats (age 35 days) were treated daily by gavage with 0, 10, 100, and 1000 mg/kg body weight of di-n-octyl phthalate from day 35 to day 49 after birth. " 12/01/2014 - "Estimated dietary exposures were also equally high and dominated by DEHP and DiNP (400-500 ng/kg body weight (bw)/day), followed by di-iso-butyl phthalate (DiBP), di-n-butyl phthalate (DnBP), di-n-octyl phthalate (DnOP) and di-iso-decyl phthalate (DiDP) (30-40 ng/kg bw/day). " 01/01/2009 - "In order to comparatively assess the systemic toxicity and sperm parameters, nine phthalate diesters, including di(2-ethylhexyl) phthalate (DEHP), di(n-butyl) phthalate (DBP), di-n-octyl phthalate (DnOP), diethyl phthalate (DEP), butylbenzyl phthalate (BBP), dimethyl phthalate (DMP), di-isodecyl phthalate (DIDP), diundecyl phthalate (DUP), and di-isononyl phthalate (DINP), and five phthalate monoesters, including mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBuP), monobenzyl phthalate (MBeP), monoethyl phthalate (MEP), monomethyl phthalate (MMP), and phthalic acid (PA) were administered orally to Sprague-Dawley male rats at 250 (phthalate monoesters and PA) or 500 mg/kg body weight (bw)/d (phthalate diesters) for 4 wk. Liver weights were significantly increased in g roups treated with DEHP, DBP, BBP, DIDP, DINP, MEHP, and MBuP compared to the control. "
2.	Overweight 01/01/2021 - "An interquartile range increase in di-n-octyl phthalate (DNOP) metabolites concentrations at 6 years was associated with an increased risk of overweight at 6 and 10 years (odds ratio: 1.44; 95% CI: 1.11-1.87, and 1.43; 95% CI: 1.09-1.86, respectively). "
3.	Neoplasms (Cancer) 09/01/2022 - "Health risk assessment suggests that the non-cancer hazard indexes (NCHI) of dimethyl phthalate (DMP), diethyl phthalate (DEP), DBP and di-n-octyl phthalate (DnOP) in all samples for farmers were at acceptable levels (NCHI < 1), and the average carcinogenic hazard indexes (CHI) of butyl benzyl phthalate (BBP) and DEHP for farmers were 3.79 × 10-13 and 8.54 × 10-11 in soils, respectively, 8.23 × 10-13 and 1.95 × 10-11 in tobacco, respectively, which were considered to be very low level (CHI < 10-6). "
4.	Hypogonadism (Hypergonadotropic Hypogonadism) 01/15/2021 - "In conclusion, di-n-octyl phthalate induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function and prevents sperm production." 01/15/2021 - "Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function in male rats."
5.	Hyperplasia 01/15/2021 - "In conclusion, di-n-octyl phthalate induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function and prevents sperm production." 01/15/2021 - "Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic function in male rats." 01/15/2021 - "Di-n-octyl phthalate significantly induced Leydig cell hyperplasia (increased number of CYP11A1-positive Leydig cells) at 100 and 1000 mg/kg. Di-n-octyl phthalate down-regulates the gene expression of Cyp11a1, Hsd3b1 and Insl3 in individual Leydig cells. "

Related Drugs and Biologics

1.	Diethylhexyl Phthalate (DEHP)
2.	Dibutyl Phthalate (Butyl Phthalate)
3.	4-boronic acid benzophenone
4.	phthalic acid (phthalate)
5.	butylbenzyl phthalate (benzyl butyl phthalate)
6.	diisodecyl phthalate
7.	dimethyl phthalate (dimethylphthalate)
8.	dinoseb (DNBP)
9.	diethyl phthalate
10.	1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)