6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)

Also Known As:

Trolox; (+--)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (+--)-trolox; (R,S)-6-hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid; 2h-1-benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-; 2h-1-benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (+--)-; 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2- carboxylic acid; 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2h-chromene-2-carboxylic acid; KH176; Trolox C; 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl- 2H-1-benzopyran-2-carboxylic acid

Networked: 333 relevant articles (19 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromans: 3
        6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid: 333
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromans: 3
        6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid: 333

Experts

1.	Percário, Sandro: 5 articles (05/2015 - 01/2006)
2.	Beyrath, Julien: 4 articles (01/2019 - 01/2015)
3.	Lee, Sun-Mee: 4 articles (05/2004 - 12/2002)
4.	Tang, You-Zhi: 3 articles (11/2020 - 03/2007)
5.	Erel, Ozcan: 3 articles (07/2013 - 11/2003)
6.	McAnulty, Steven R: 3 articles (07/2013 - 03/2008)
7.	Bloomer, Richard J: 3 articles (09/2012 - 11/2007)
8.	Eum, Hyun-Ae: 3 articles (05/2004 - 12/2002)
9.	Koopman, Werner J H: 2 articles (01/2022 - 01/2015)
10.	Smeitink, Jan A M: 2 articles (01/2022 - 01/2015)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2017 - "Furthermore, there was no alteration in RVSP during hypoxia in the presence of Trolox. " 01/01/2016 - "The radical scavenger trolox C reduced the Isc response during hypoxia, but failed to prevent the rise of Isc during reoxygenation. " 10/01/2014 - "Furthermore, compared with Trolox, Trolox-CSNPs exert a higher protective effect against the hypoxia-mediated oxidative stress. " 02/01/2014 - "NEU, at a low dose (1 μM), competently depressed the hypoxia-induced convulsive activity in a manner similar to trolox. " 01/01/2014 - "We confirmed in Mecp2 (-) (/y) hippocampus that Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves the hypoxia tolerance. "
2.	Ischemia 12/01/2002 - "H-2954 exerted significantly lower protection against ischemia-reperfusion-induced myocardial injury than H-2545, and it was comparable to that of Trolox. " 06/01/2016 - "Shuttle box results showed an improvement in memory in the Trolox group compared to the ischemia group, however, these improvements were not signifi cant. " 12/01/2002 - "Trolox C ameliorates hepatic drug metabolizing dysfunction after ischemia/reperfusion." 06/01/2016 - "In this study, for the fi rst time, we evaluated the effects of Trolox as an antioxidative agent in ischemia induced by reperfusion. " 06/01/2016 - "Ultimately, as an anti-apoptotic factor, c-JUN was increased statistically in the Trolox group compared to the ischemia group (p < 0.01). "
3.	Reperfusion Injury 06/01/2016 - "Neuroprotective Role of Trolox in Hippocampus after Ischemia Reperfusion Injury in Mouse." 01/01/2010 - "All these effects indicate that Trolox protected the transplanted heart, at least partially, against ischemia-reperfusion injury." 08/01/2007 - "Renoprotective effect of trolox against ischaemia-reperfusion injury in rats." 03/01/1991 - "Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury." 11/01/2012 - "The aim of this study is to investigate the effect of Trolox alone on the intestinal ischemia-reperfusion injury in strangulation ileus model, which has not been investigated previously. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2019 - "The results of the study provide first data on safety and efficacy of KH176 in patients with mitochondrial disease and will be instrumental in designing future clinical trials." 01/01/2019 - "Trolox pre-treatment significantly blocked neuronal apoptosis, ER stress, UPR activation, as well as mitochondrial dysfunction, in addition to the direct anti-oxidation. " 01/01/2019 - "KH176 is a potent intracellular reduction-oxidation-modulating compound developed to treat mitochondrial disease. " 10/16/2017 - "KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers." 01/01/2017 - "These in vivo findings show that further development of KH176 as a potential treatment for mitochondrial disorders is worthwhile to pursue. "
5.	Fibrosis (Cirrhosis) 07/01/2017 - "From the histological examination, the Trolox-treated groups presented a higher cellularity at Week 2 as compared to the saline group, and reduced fibrosis and adhesion at Week 6. Our results suggest that local administration of Trolox can reduce tendon adhesion, and a higher dose of Trolox did not have negative effects. " 11/01/2008 - "We found that trolox effectively prevented cirrhosis induced with CCl4 in the rat. " 06/01/2013 - "Trolox mitigates fibrosis in a bile duct ligation model." 05/21/2015 - "Although Trolox improved follicular quality and avoided apoptosis in stromal cells, ovarian tissue fibrosis was increased in Trolox-treated grafts, mainly due to an increase in collagen Type I synthesis." 11/01/2008 - "Therefore, we decided to study the effect of trolox, an effective antioxidant, on experimental cirrhosis. "

Related Drugs and Biologics

1.	Antioxidants
2.	Vitamin E
3.	Allopurinol (Remid)
4.	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)
5.	Ascorbic Acid (Vitamin C)
6.	Cysteine (L-Cysteine)
7.	Xanthine Oxidase
8.	Chitosan
9.	Blood Glucose (Blood Sugar)
10.	cytisine

Related Therapies and Procedures

1.	Resuscitation
2.	Therapeutics
3.	Heart Transplantation (Grafting, Heart)
4.	Photochemotherapy (Photodynamic Therapy)
5.	Intraperitoneal Injections